Case from my practice.

 Patient, on 42 y.old with abundant weight , height  175 cm, weight 80 kg, index mass of body 26.12 /abundant weight/, she addressed to the doctor with complaints on weight increasing, analyses by doctor s done, and stayed on limits   a norm by dates of laboratory referent meaning and by doctor s rate:

Glucose on an empty stomach 5.7 mmol, HbA1c 5.8 . On  the true and 5.7 mmol/l, and Hba1c  are stats for destroyed tolerance to glucose  and pre-diabetes. As,   am again mentioning you, that  meaning Hba1c is higher on 5.7  is meaning on pre-diabetes  having , and optimal level for glucose on an empty stomach is not rises on 4.9 or maximum on 5.6 is an  unfavourably.

Test by Hayashi in our hospital done shown as hard insulin resistance :

Insulin on an empty stomach 26 Mme/l, Insulin in 60 min 160 MmEl/l, in 120 min  is 216 MmEl/.

 And by method a interpretation test, a maximal rising level of insulin is allowing just on intervals on 30-60 min since test begun, after he must lowering , and between 120 and 180 min is must  be a low. But achievement maximum in 120 min after test begun, as in our patient is being unfavourable, as directing on a hard hyperinsulinemia and diabetes having. A doctor in patient not found it, and she is not received  needing message and kept lived a same spirit, that confident, that  all is OK!

 Picture 8. Result by Craft test in patient with a strong insulin resistance. Compare a curve norm and curve by patient s result. And how you can to see, an insulin peak in patient has to on a time between 120 and 180 min that to say about , that insulin a long time not ability to find cells,which ar e would ready absorb an entered glucose, thus  his  quantity is so long grows. And on ideal variant insulin to 120 min already lead to , as lead initial result.

And,  also, they are absence or change /phase is delaying on a few hours, in adults with diabetes of 2nd type.

 Therefore, and test on tolerance to glucose ,  when used in patient with obesity or other metabolic destroys, are will be a normal, and here will be a fault as shift for circadian    rhythm of tolerance to glucose. Thus,  such test need to do on other time or other day, and he will show are changes  presences.

Dear doctors, please take attention more on such peoples!