Am often reading vestnik, and never met or saw a such diseases eosinophil granulematosis with polyanginitis , that is having in my daughter after Covid endured. Maybe a reason is nerve breakdown, on her 40 years ol, she is having two children's schoolers . Please help, say about this disease, about a cure, and herbs, which prognosis is here?
Eosinophil granulematosis with polyanginitis is ANCA is associated systemic vasculitis for vessels damaging by small and middle hummingbirds . Also having bronchial asthma, eosinophils high containing in blood, that displaying much eosinophil infiltrates in organs and tissues.And in these group of vasculitis entering granulematosis with polyanginitis as Wegner s and microscopic polyanginitis. And in data disease in blood finding antibodies especial to cytoplasm neutrophils/ANCA/. If to talk about a disease reasons as much rheumatological diseases are not simple to find. By practice that Eosinophil vasculitis is a selecting for target is respiratory highway as with a long staying bronchial asthma, allergy rhinitis, nose polyps, endured a hard COVID-19, serious nervous breakdowns, over cooling, acute respiratory diseases often. They are all having trigger or risks factors. And if in diagnosis having troubles, when doctor not finding ANCA in the blood ,thus doing biopsy of damages organ or tissue under microscope to find signs for eosinophil vasculitis. And half of patients having sensitive destroying, forces in legs, hands, as of periphery nerves damages, lots of times are having restoring or years, also meeting heart damage lungs, bowel, kidneys, joints,skin. All organs are rich with blood supply ,thus are here a risk for other problems are myocarditis, infarctus, periphery neuropathy, haemorrhagic stroke, gastroenteritis, perforation bowel. Meeting in peoples from 15 to 70 y.old, but more often in Middle Ages as 40–50 years.In vasculitis kinds cure is serious from 2 and more years, and serious. Its combined immunosuppression , in base of which are having prednisolone, cyclophosphamide, or rituximab. And on begin cure dosages are 60 mg /day, or by dropsy with methylprednisolone, in a 3 months daily prednisolone dosage lowering on 10-15 mg, in half year till 5 mg, but a few patients using high dosages within a long time. Or in a cure of half years -year since cure begin are cancelling prednisolone, but condition is worsening, thus small dosages of hormones leaving on the continuing time. But in prescribing cyclophosphamide is high risk for damaging organs and tissues. Thus, use by dropsy on every three weeks with course till 6 months with a following transfer on the softer remedies as azatioprine, or methotrexate. Thus, cyclophosphamide is very toxic, thus within all cure course, drink more water. An alternative for cyclophosphamide is rituximab, its biologic remedy destroying lymphocytes, where in data vasculitis are straying for factories of antibodies are damaging vessels.Rituximab is his other name mabtera, accelbia as by dropsy prescribing. Beginning course 4 infusions on 500 mg, and for future we are repeating cure on same dosages ,which prescribing doctor. But by me just prednisolone a granulematosis ia therapy using, and other remedies not an always needing, But stay ready, in lowering dosages for glucocorticosteroids is acuting going. Its acuting not of vasculitis, but bronchial asthma, allergy rhinitis, thus will help you anti-asthmatic and anti allergy remedies, which you are using before ,as a modern biologic remedies mepolizumab. And for calming, which are calling by me three vasculitis kinds , as eosinophil vasculitis is less dangerous for life, but here is high risk for damaging periphery nerves, cure is serious, with rheumatologist checking, self cure avoiding. And with herbs. Thus, your daughter not upset need, hands down, a fight is long, serious, but she will be an effective.
By I.Smitienko, rheumatologist, candidate for medical science.
