Which role plays fat and leptin in insulin resistance?

 Gain for lipogenesis de novo/forming fat and weak lipolysis as splitting and decreasing fatty mass in fatty tissue are depending from glucose level in blood, and quantity of insulin, secreting by pancreas gland. Lipogenesis gain in a high level of glucose in blood, and lipolysis in low. A many quantities of insulin stimulates lipogenesis ,and small quantity of insulin inhibits /depresses/ a lipogenesis. Thus, abundant  of glucose in blood and high level of insulin stimulates forming and depositing fat in insulin resistance peoples. Remember it! Thus,   a one from base methods   ,which helps keeps a normal weight and avoiding  rising level of glucose and insulin.

Fatty tissue secrets a whole rows of biologically active mediators, calling adipokinesis /adiponectin, leptin , hemerin, resistin, visfatin, and  vaspin/. in additional to cytokines and chemokines  /factor necrosis of tumor -alpha  -a, interleukin  -a 6/IL-6, IL1b, and  monocitary  chemoattractate protein-1. Destroying and manufacturing these  adipokines, ties with increasing of size a fatty tissue n obesity and decreasing her split, associating  with obesity insulin resistance , diabetes 2 nd  type, cardiovascular diseases, hypertension, and different metabolic destroys. Thus, a this  fat, which having  in your bad is hormonal active organ, which a self to cause a disease , if he is abundant and deposited in wrong place, where is not must to be, and if he is not much. Thus,  a fat is a neutral  fat.

A let s detailed check are two importance adipokine  a hormonal same substance adiponectin and leptin. 

Adiponectin is a most secreting  protein of fatty tissue , as with a power anti-inflammatory   effects , and in compare from other adipocines, in obesity  and insulin resistance a level for adiponectin  is lowering under affecting of ant inflamed agents/TNF-a, IL-6, ROS, that allowing predisposing  ,that  chronic inflammation tie with insulin resistance and contrary.

Leptin. Also,  hormone saturation, is cytokine ,which manufacturing by fatty cells.As in norm he is affecting on weight lowering, manufacturing glucose level lowering in liver, normalizing level of glucose in blood and rising sensitiveness of cells to insulin,that is useful and importance!Leptin depressing manufacturing insulin in beta-cells of pancreas gland,that helping to prevent insulin resistance of tissues. Insulin here stimulates secreting leptin from fatty tissue, creating a loop of back connect with hormonal regulation.

  And am sharing detailed this. Stomach hormone is ghrelin   is starving hormone rises appetite and eating meal, and leptin is saturation hormone, manufacturing by fatty cells, lowering appetite and meat eating. When you are eating, organism manufacturing leptin, level of which slowly rising, and saturation feeling ,when leptin level lead a limit, signing for brain ,that you are saturated, your stomach is full. Insulin, level of which also rising and on the time , lowering feeling starving in healthy peoples  and stimulates secreting leptin, but leptin beginning depressing manufacturing insulin, so as a slowly rising till a high levels and on the meal time.

And these substances are affecting on inflammation development, secreting by abundant peritoneum fat, liver, and immune cells of blood. Adinopectin also manufacturing by fat, as more  in organism quantities of bad food,thus a more  manufacturing these inflammation substances, which depressing a positives anti  inflamed effect of adinopectin , causing an inflammation.

 An importance!If you are over eating and having obesity, or in your ration are much carbohydrates , your organism can be manufacturing much leptin, than usual , that lead to the calling leptin resistance  is lowering of cells sensitiveness to leptin , analogically  in insulin resistance. And this low control over hungry feeling and rising development for insulin resistance. And contrary,  a chronic raised level of insulin in blood and insulin resistance  also rising level fo leptin in blood and affecting for development leptin resistance. A high level of leptin in blood with obesity  and insulin resistance affecting on removing anti-inflammatory /affecting  for inflammation such connects as IL6, TNF-a, IL-12  , SO ARE ALL CLOSED TIED!

Other extreme is leptin deficit , as meeting rare. Deficit such lead to insulin resistance , which will stay a reason for hard and hard curing forms of diabetes, and triglyceridemias rising triglycerides in blood, which lead to pancreatitis, such patients an still not saw.

 Ideal test on leptin resistance is not having , and most spreading  is a calculated for index free  leptin, which doing at hospitals, as specializing on metabolic destroys, but in Estonia , non hospitals is not defining index for free leptin.  And defining simple leptin in blood on an empty stomach is having small diagnostic value-his for example is ability to check with insulin on an empty stomach, but am this test using rare.In women's leptin level is not must to rise on 7-10, in males are 4 units on a morning emptiness.

Losing weight is affecting an importance on insulin effect,and lowering weight on 5 perc. Improving sensitiveness of many organs/fatty tissue, liver, and skeleton muscles /to insulin.

 

Why tests on blood are doing on an empty stomach?

 As for a most parts are tests not needing limiting, but a few are doing on an empty stomach and wake on on an early time, and this is importance needing.

And such method is needing lowering probably  error  in diagnostic and to interpretation  her results, and this is happening in blood test.

As manufacturing hormones, ferments activity and cells quantity in periphery blood changing within a day, and after meal happening fast changes.And doctor in decoding analyses compares your dates with a conventional norm,and these are averaging results for a healthy person, which done blood test is on an empty stomach, and norm for an evening test or analyses after eaten sandwich is not having. And other ,that a widen borders for norm usually forgive error in the meal, time a day, and your result will be in a limit for tolerance and even shifting a little up or down, but an importances exclusions having.

On which are affecting a time of the day?

And a first are on a hormones level, and hormones test level better doing on a half first day,thus result will be a weak informative. Concentration somatotropic  hormone cortisol and  adrenocorticotropic  hormone are on the morning and evening very difference on 2-4 times, daily differences hormones for thyroid glands are leading 20 perc. from a middle level, and testosterone can raise and lowering within a day on the half. And also urine test is very sensitive within a day, and for right result getting taking urine is on the morning as right away after waking up. Second and following portions are differencing by an own structure, thus a sleep before analyse need to have 6-8 houses as against urine bladder filling urine with a right concentration of diluting substances. And if you are staying awaking a morning urine is not differencing from a daily or evening and here are hormones fault.

 

And belly cancer was been calmed.

 I am having a systemic disease, as of abundant using hormones, remedies my bowel feeling sick, and absorbing vitamins and iron are destroyed, bad enduring meal, as milk, not stopped diarrhoea, feeling often meteorism ,  rumbling, bubbling  are in the belly, such converts are kept all day.

And probiotics not helped and one friend advised me to drink infusion of  burnet roots as recipe is not hard as one tbl.sp. chopped dried roots added in glass of hot water, boiled on weak fire for 30 min, infused 2 hours,filtered,am used on 2 tbl.sp. for 6 times a day.And cured by this method for week am saw a white light ,as in a belly stopped concerts, as belly calmed, stool is normal, diarrhoea stopped,thus am using such cure courses as regularity.

And on the last years I had erosion gastritis as everyday test showed. After regular used burnet erosion not found, but take care she is rising blood coagulation,and against thrombosis am using remedies for blood diluting.

Problems are of stress.

 Am very hope to receive practical advices for a thyroid cure, and on ultrasound found cysts, am curing am within a year as on different dosages as 6 months used eutirox, 6 months are l thyroxine,and condition not improved, just worsened, thyroid pressing more stronger, as in swallowing something feeling, four years having insomnia, and go to sleep on 22.00 as used mixtures of crataegus, leonurus, peony, mint or, and very rare hold up till 4.00 am,as waking up with a strong headache and noise in head, sedative not helps. And thyroid gland problems was been at school,as on ten class am felt headaches, worsened memory, mum visited a doctor with me, and 2  months used iodine balls, was been improves, but not as till a diseases,as health worsened after one case, as 4 years ago am in village and on the rail station was been attacked on me, am alive, as on right leg are two fractures, suffered head, spine, hands, and one night worker helped me, as called for doctor, at hospital taken blood and haemoglobin as 8, doctors prescribed iron pills, as on the second day thyroid was suffocated me, as used week, am stopped used remedy, and press felt less, but not stopped, and on the morning having ache in swallowing,like lump in throat, nerve system is a not good, worsened memory.

Dear Larisa, answers endocrinologist Tarhanjan as to rate as a how on a background using therapy functioning your thyroid, thus needing a constant control for TTH , T4 AND your anamnesis as when diagnosed iron deficit, low haemoglobin and common blood test, level for ferritin, as a index by a judge about a quantity stocked by organism an iron. And your complaints are conditioned by a stress factor,as after you accident survived ,as in normal size a thyroid gland with cysts is not leading to asphyxia ,as cysts are small cavity forming with a liquid containing in ultrasound test finding are often, they are not dangerous, just checking theirs for one time a year, and if they are growing,thus needing consultation surgeries endocrinologist as for puncture   nodule forming,that very rare having.As this test helping understand a structure for nodules and about that they are benign or malignant, which are not needing removing. As a feeling,like lump in throat is forming of your stress and worry , but if pressing is keeping , thus a needing consultation by endocrinologist surgeries, as repeat ultrasound for thyroid, CT for neck, as to understand a how a thyroid is a reason for pressing,and if this is exception,thus a needing neurologist consultation. And clinical displays here are weakness, tiredness, changing mood , irritability, wordiness are often happening in functional destroys thyroid gland, and if patient using L thyroxine or eutirox without a regular hormones level checking,thus a dosage for remedy is hard controlling,as a probably having his failure or abundant ,and this lead to complaints as in you. 

And by your age, and not regular visiting for specialist as for a full rate an own condition thus a needing knowing about cardiovascular diseases in you  as destroys,thus check analysis for cholesterol, lipoproteins for low density, triglyceride, metabolism destroy as control glucose as for diabetes exception .And to understand,that a thyroid gland work right of microsegments failure, thus doing tests and on iron contain, mg, vitamins groups B, zn and selenium.

Very importance analyses.

 And today we are sharing kinds of blood tests.

Test on hormones.

As other importance blood tests helping to define are destroys in organs and organism systems. And here are tests on hormones blood test.

As hormones are biologically active substances,regulators for metabolism and organism functions.As forming in a cells of glands inside secretions and a few other tissues,they are secreting in blood a lymph.  And on Crete hormone means as prompts ,lead in mobility.A normal hormonal background activates protection organism forces as giving his agreed work, timely reacting on a different destroys and failures. And containing hormone depending from age and sex,and ejection any hormone in blood current is higher on the morning and lower on evening, and entering theirs in blood regulates a nerve system.

As long rising or lowering hormones synthesis ,than in norm is a reason for many diseases and a few symptoms are directing for needing testing on hormones. And tachycardias, sweating,edemas, faster weight rising or lowering as without diets, hairs falling out, voice hoarseness, menses cycle destroy, dryness skin, changing mood, irritability,sleepiness or insomnia.

And test blood in male allow to find sterility, obesity reason, potency destroy, and in women's concentration hormones changing on pregnancy, climax, and on a few remedies using.

Preventing for menses migraine.

As usual preventing in menses migraine receiving a small improving, as tried cured with hormones is not satisfactory, and preventing needing,when attack keeping more,that 3 days, and a using for emergency  therapy is not enough. And a most hope method here is analgesic using with an anti iniflammed effect as before two days till menses beginning or one day after,as this is naproxen on 500 mg for 2 times/day, or ibuprofen on 600 mg for 2 times/day, or you can use for a short preventing is ergotamin or triptans,as in claster headaches .

Endometriosis is about.

Ten years ago  he was been a rare disease ,and today is often meeting. Endometriosis is disease,calling for tissue growing,like endometrium, is inside mucus membrane of uterine, and in organs. And symptoms are same,like in other diseases,as in inflammations of uterine ducts,acute appendix, or bowel s obstruction, and of a new tests investigations are hysterosalpingography, hysteroscopy, laparoscopy is to recognize this diseases and to prescibe a right cure. And a most often reasons for endoimetriosis are abortions, as on artificial stopping pregnancy, even by right method is injuring muscle layer of uterine,leading to growing endometrium in her cavity, and parts of mucus membrane ingrown in back of uterine cellulose and here display as endometrioid nidus. As entering parts of endometrium in other organs also in menses time, in uterine bend, or narrowing her canal neck, when a natural current of menses blood is hard, and she entering in peritoneum cavity through uterine tubes. And display of endometriosis having of endocrine destroys. And he can to display in any organ and tissue of female organism, as in uterine, her neck, tubes, ovaries, in external sex organs, scars after Cesarean births cuttings, in crotch, in urinary bladder, bowel, eyes. And they are having a cyclic changes ,that mucus membrane of uterine. Endometrian niduses to menses time are swelling, and enlarging in sizes,and here is rising of diseases display in pre menses cycle, and displays are different, just depends from a place of position growing. And after menses women feeling healthy, but with a next menses repeating again and this on an every cycle. And on the hard cases that ache syndrome weaks, just on middle menses cycle,but patients feeling aches of different intensivity.And often indisposition lead to irritability, depression, insomnia, appetite loosing . And many women's interesting that endometriosis lead to tumor?Scientists could not find an opinion, and endometriosis is process benign. but a few think,that maybe, but rare lead to tumors.And am advising you you must all to do for prevent a diseases, as to avoid abortions, with preventing theirs are today prescribing many different contraceptives, if you are pregnancy, and if her need to stop, thus to do this till 8 weeks, when a less injuring muscle of uterine, and less risk for endometriosis. And against entering parts of mucus membrane from uterine in peritoneum is an importance on menses do not rise heavy loads, items, avoiding physical loads, sex life, even blood secretions are not clear. And women with endometriosis often needing checking in a doctor, which to stop pathological process as on an early stages, and very effectively is hormonal therapy, which suppress a grow of endometrioid tissue and assisting her slow substitution a connective tissue. And prescribing a cure doctor attention on the reaction of organism in women on the hormones as selecting theirs. And cure doing with under his checking. And if hormones are not help, thus doing surgery. And practise shows,that a good cure for endometriosis are pregnancy and birth, so as on pregnancy time and in all stage of breast feeding a baby are cycle changes in uterine stopping.

Base cure for arteritis are hormones of metipred or prednisolon, and dosages are individual, and using theirs for long time.

As for many years, but are risks for a seconds complications of hormones as stroke, hard kidney damage, kidneys failure, but steroid cure lows SSE, inflammations,and returns pulse, but on an additional help we are adding remedies  of methotrexate, azatioprin, micofenolat, mofetyl, leflunomid, and on hard stage are infliximab, certolizumaba pegol, tocilizumab, are suppressing inflammations in vessels, and prednosolon  dosages lows, and in a high risk for artery closing or in blood current absence thus adding surgery with entering many of swings is a passage way for blood, and in low diseases activity, so are rising risks for repeating vessel narrowing or bad surgery doing.And many patients asking me about a life mode, about a remedies for immunity using, sun bath taking, exercises doing.. And in meal nothing prohibited, limiting are flour,sweets, breads, where in risk for obesity are and of prednisolon, as salt limits as a provoking hypertension, and not using immunomodulants,they are activating vasculitis, but yes, use vitamins, as of drug store or meal, add sport, but, not till fanatism, as regular loads blood circulation rising in hands and very importance in under clavicle arteries, as not visit for sun for the long time, its stress for organism, not visiting hot bath,sauna,spa, beach, avoid smoking, smoke is bad for vessels, rising atherosclerosis process, and with years hormones are lowering, but not leave disease for spontaneity.

As to keep muscles in tone.

As and muscles are about, as in a hug of polymiositis they are lost tone, fdorce, as additional attacked of hormones ,as causing muscle atrophy, thus for theirs restoring are needing try, as of remedies raising energetic metabolism in muscles am advicing vitamins of L carnitin-lipocels, L carnitin 300, are till 3 gr/day for the long time, as not deprending from the meal time. As after acuting am advicing using gymnastic, for a keeping in tone are muscles hips, shoulder waist, neck with squats, head turns, for bending   and bending out extremities,and walk, as Scandinavian with sticks, swim, bycicle walks. As for a disease penetrating you need to attend, as eating meal rubbing as after 19.00,asfor avoiding meal s mass entering in gullet and avoiding eating.
In swallowing hard as sleep on the bed with rised head.
As avoiding clear sun rays, as reacting this disease on his acuting, do not contact with infected patients, not stress.
Train, train muscles, if you cannot wake up, think an own exercises and doing through you cannot, as  in muscles are prohibiting a bad processes happening.

Eczema is about.

As inflamed skin disease of nervous allergy character, as display on the answer on affect of external or inside imitators are with polymorphous rashes,itching, Long recidiving display, as and reasons are stress, worries, endocrinopathias, gastrointestinal diseases, liver, allergy, as on children s age as in neurodermitis.

Symptoms are periods eczema  are on strong stress, bladders are with transparent liquid, redness skin,peels, top skin pieces , as in acute till chronic stages are skin thickness, peelings, very strong itches, eczema rashes are on hands back top, elbows,elbow bending, under knees sides, groin, face.

As cure is in dermatologist with a fighting stress, sleep better with anti histamines, sedatives in edema,wetting are acute are diuretics, calcium, vitamin c, rutin, locally apply cooled lotions of  furacilini, black tea,dryness paste of boric naftalan, boric birch tar, Zn salicylic, and ointments are glucocorticosteroids, as selecting are  with a doctor for avoiding chronizations process, hard eczema with a strong displays are using prednizolone , triamcinolon, as cure at stacionarum.

Diet here are lowering salts, salted meal, in gastric problems adding stewed meal, baked , not fried, as regular stool for fighting is hard stool with diet/check/, adding vitamin c, bioflavonoids are walls vessels strengthening, in allergy on milk avoiding milk , but if no, adding calcium of milk, sour milk, not salted cheese are anti allergy, anti inflamed effect.

As local cure are afloderm, laticort, advantan.

Anti histamines are psilo balsam, fenistil.

Anti allergy are fenistil, tavegyl, loratadin, zirtec, erius.

PMS is about.

 As disordering function of nerve,cardiovascular, and endocrine system are before menses, as on 16-20 and after 35 y.old, as tied in dysfunction ovaries, high estrogen's on the last cycle days, abortion, uterine tubes over bandages, bad contraception, infections, pathological pregnancy and births.
And also risks are high in depression,stress, caffeine addicted,salts, alchokol, liquid of, age as older on 40 y.old.
Symptoms are before a week sumptomes are beginning.with dizziness, headache, insomnia, nausea, tremble, fatigue, aches in breast, edemas, arrhythmia's, panic attacks, asphyxia, high temperature, sweating, hypertension, breast behind heaviness, fears for dead, chill, numbness extremities,as these are having in the different combinations, which are consulting in gynecologist or endocrinologist.
As here are doing tests by menses beginning complaints, as within two months, as evidence as PMS a curing for symptoms and absence theirs on a first half menses cycles.
Cure are in light form are spa,water, gymnastic,.massage, diet on the half second cycle, regime for work, rest, using diuretics with panangine, aspartame, homeopathy sedatives, as in high serotonin, and histamine are high allergies having, thus and anti histamines adding, on the hard stages are hormones, by a blood tests on the hormones and diseases an other .

Diet are less liquid drinking, limiting meal are rising symptoms are alchokol,caffeine, milk, salts, fats, chocolate, rising are calium, as dried fruits, cabbage.
Sedatives are valeriana, leonurus, novopassit, belliod, bellaspon, persen.

Diuretics are hypoptiazidum, diacarb, veroshpiron, triampur.

Tranquilizers are diazepam, nitrazepam, tazepam, eleniu,/

Anti histamins are tavegyl, erolin,suprastin, erius.

Homeopathic are dismenorm, climadion, mastodion, remens, ciclodion.

Diet in climax.

Healthy meal is,with poly vitamin regular using, on one dragee/day, calcium meal, as against bones fragility, as limiting smokers, fats, pastry,yeast, hard meal,caffeine, strong tea, and very good diet using,if climax worsening diabetes, hypertension or osteoporosis,thus diet using in this process/check labels/.

Remedies are non hormonal anti climax are climatoplan, remens, saginit, cimicifuga, climadinon.

Sedatives are valeriana, leonurus, novo passit, belloid, belaspon, persen.

Tranqulizers are diazepam, tazepam.

hormones are climen, climodien, climonorm, cliogest, pauzogest, proginova, femoston.

Hyperthyreosis is about.

As thyreotoxicos is ache syndrome, with  a high function activity for thyroid gland, as high producing theirs hormones in blood, as in thyroid diseases is diffusion toxic goitre, adenoma toxic for thyroid, and hypophisis, here where are genetically factors, infections, intoxication's, psychic injuries, immune bad,which forming antibodies are stimulating effect on the cells of thyroid gland, leading her growing and activity, as he leading to activation for metabolism, energy burning for a protein splitting and tissue fat, as high loosing glycogen in muscles and liver and secretion from organism calium , calcium and phosphorus.

Symptoms are irritability, cry, insomnia, weakness, fatigue,sweating, high temperature, chill, tachicarditis, arrhythmia, tremble body, hands, thin weight, exophtalm, goitre nodule, as pulsation till 140 hits/minute, heart failure, liver damage.

At hospital, but in a symptoms these call a doctor.
You are getting a tests for a finding reasons for thyroid damaging, are of pulse checking, pressure, thyroid, weight, as blood test on hormones concentration, urea tea, scull bone forming, on calcium, phosphorus, cholesterol, are on T3, T4, TOTH, autoimmune antibodies to the thyroid gland, ultrasound for thyroid, biopsy for thyroid.

Yes, am understood about are drugs using, but what about a rules in lupus needing keeping.

A sun is very bad for you, as acuting process happening on the sun days,therefore wear hats, clothes as cotton of, glasses and creams apply, as any over heating,are bath, sauna as avoiding for you, also as smoking,stress, but we never knew what are happening with immunity, which is broken , but these facts are provoking lupus, as and estrogen's, immune modulates,which are not using for you.