Which role plays fat and leptin in insulin resistance?

 Gain for lipogenesis de novo/forming fat and weak lipolysis as splitting and decreasing fatty mass in fatty tissue are depending from glucose level in blood, and quantity of insulin, secreting by pancreas gland. Lipogenesis gain in a high level of glucose in blood, and lipolysis in low. A many quantities of insulin stimulates lipogenesis ,and small quantity of insulin inhibits /depresses/ a lipogenesis. Thus, abundant  of glucose in blood and high level of insulin stimulates forming and depositing fat in insulin resistance peoples. Remember it! Thus,   a one from base methods   ,which helps keeps a normal weight and avoiding  rising level of glucose and insulin.

Fatty tissue secrets a whole rows of biologically active mediators, calling adipokinesis /adiponectin, leptin , hemerin, resistin, visfatin, and  vaspin/. in additional to cytokines and chemokines  /factor necrosis of tumor -alpha  -a, interleukin  -a 6/IL-6, IL1b, and  monocitary  chemoattractate protein-1. Destroying and manufacturing these  adipokines, ties with increasing of size a fatty tissue n obesity and decreasing her split, associating  with obesity insulin resistance , diabetes 2 nd  type, cardiovascular diseases, hypertension, and different metabolic destroys. Thus, a this  fat, which having  in your bad is hormonal active organ, which a self to cause a disease , if he is abundant and deposited in wrong place, where is not must to be, and if he is not much. Thus,  a fat is a neutral  fat.

A let s detailed check are two importance adipokine  a hormonal same substance adiponectin and leptin. 

Adiponectin is a most secreting  protein of fatty tissue , as with a power anti-inflammatory   effects , and in compare from other adipocines, in obesity  and insulin resistance a level for adiponectin  is lowering under affecting of ant inflamed agents/TNF-a, IL-6, ROS, that allowing predisposing  ,that  chronic inflammation tie with insulin resistance and contrary.

Leptin. Also,  hormone saturation, is cytokine ,which manufacturing by fatty cells.As in norm he is affecting on weight lowering, manufacturing glucose level lowering in liver, normalizing level of glucose in blood and rising sensitiveness of cells to insulin,that is useful and importance!Leptin depressing manufacturing insulin in beta-cells of pancreas gland,that helping to prevent insulin resistance of tissues. Insulin here stimulates secreting leptin from fatty tissue, creating a loop of back connect with hormonal regulation.

  And am sharing detailed this. Stomach hormone is ghrelin   is starving hormone rises appetite and eating meal, and leptin is saturation hormone, manufacturing by fatty cells, lowering appetite and meat eating. When you are eating, organism manufacturing leptin, level of which slowly rising, and saturation feeling ,when leptin level lead a limit, signing for brain ,that you are saturated, your stomach is full. Insulin, level of which also rising and on the time , lowering feeling starving in healthy peoples  and stimulates secreting leptin, but leptin beginning depressing manufacturing insulin, so as a slowly rising till a high levels and on the meal time.

And these substances are affecting on inflammation development, secreting by abundant peritoneum fat, liver, and immune cells of blood. Adinopectin also manufacturing by fat, as more  in organism quantities of bad food,thus a more  manufacturing these inflammation substances, which depressing a positives anti  inflamed effect of adinopectin , causing an inflammation.

 An importance!If you are over eating and having obesity, or in your ration are much carbohydrates , your organism can be manufacturing much leptin, than usual , that lead to the calling leptin resistance  is lowering of cells sensitiveness to leptin , analogically  in insulin resistance. And this low control over hungry feeling and rising development for insulin resistance. And contrary,  a chronic raised level of insulin in blood and insulin resistance  also rising level fo leptin in blood and affecting for development leptin resistance. A high level of leptin in blood with obesity  and insulin resistance affecting on removing anti-inflammatory /affecting  for inflammation such connects as IL6, TNF-a, IL-12  , SO ARE ALL CLOSED TIED!

Other extreme is leptin deficit , as meeting rare. Deficit such lead to insulin resistance , which will stay a reason for hard and hard curing forms of diabetes, and triglyceridemias rising triglycerides in blood, which lead to pancreatitis, such patients an still not saw.

 Ideal test on leptin resistance is not having , and most spreading  is a calculated for index free  leptin, which doing at hospitals, as specializing on metabolic destroys, but in Estonia , non hospitals is not defining index for free leptin.  And defining simple leptin in blood on an empty stomach is having small diagnostic value-his for example is ability to check with insulin on an empty stomach, but am this test using rare.In women's leptin level is not must to rise on 7-10, in males are 4 units on a morning emptiness.

Losing weight is affecting an importance on insulin effect,and lowering weight on 5 perc. Improving sensitiveness of many organs/fatty tissue, liver, and skeleton muscles /to insulin.

 

But its wrong would think, that from a cholesterol just a one harm.

 He is in organism doing importance functions  ,as entering in structure of all cellular membranes, of his forming are many hormones as a sex. Where an organism receives cholesterol?In first, he is synthesising in metabolism process as in liver,and from a meal absorbing in bowel, and a bad, that cholesterol entering more, than a needing for a covering physiological needing . Scientists are not informed,that abundant cholesterol accessed from a blood in tissues by special complexes , calling beta-lipoproteins, and except from cholesterol in theirs structures entering are a such fatty and fatty similar substances, triglycerides as phospholipids and especial proteins. And in a blood, every person having, and  other complexes are alpha-lipoproteins   are ability taking cholesterol  from arterial wall and give in liver. And here he is splitting and splitting his products with gall leaving from organism through bowel.

A high containing in blood alpha-lipoproteins is meaning , that process for removing cholesterol from tissue going awesome, and he is not accumulating, that risk of atherosclerosis lowering. If a common quantity of cholesterol in blood is very high, alpha-lipoproteins are not ability coping with high loading and cholesterol accumulating in arterial wall.

 As for peoples on different age and sex is right top border containing cholesterol in blood as in women's and males on 30-39 y.old are 235 ml gr on 100 ml/decilitre/ of blood serum or 6.0 mml on 1 litter. After 40 y.old in male cholesterol containing is normal, if he is not high on 260 mg/dl or 6.7 MMO .l, and for future increasing cholesterol  is a destroying for norm.

After 40 y.old in women's on  a lowering sex function is delaying manufacturing estrogens , which from a male hormones are affecting on lowering cholesterol in the blood. Therefore,   increasing his containing in women's  from 40-50 y, old is norm, but for 40- 49 y.old are 250 mg/mm or 6.6 MML, for 50-59 are 280 mg/dl, or 7.2 MML/l, and after 60 y.old are 295 mg/dl, or 7.7 MML/l/

If cholesterol lever rises a data norm, thus a need lowering meal eating with a cholesterol, and increase physical activity, thus in organism normalizing forming hormones and those, which stimulating a synthesis of alpha-lipoproteins  ,removing are abundant  of cholesterol from the blood.

 And for the lowering cholesterol quantities, which organism getting with meal, thus avoiding from ration or limiting fats kinds of meat, fish, fromage, creams, fat animals, sub products ,eggs and in meal adding  vegetable oil, as he is a such with half saturated fatty acids, normalizing lipid/fatty/ metabolism. And results from research  are  shown ,that lowering for cholesterol level influencing  containing in meal ballast substances are cellular membranes, pectin.  And,  theirs are much in raw, boiled vegetables, beet, carrot, cabbage, sweet pepper, radish,turnip, cucumbers and in apples, fruit juices with pulp natural. Ballast substances in bowel adding to yourself a cholesterol of food and removing his from organism, preventing absorbing in blood.

 As on the picture in circle are shown  a narrowing for base arteries of a  heart, caused by atherosclerotic damages.And,  in result destroyed blood supply and oxygen for myocard part/1/, where are having arteries .

 

10 facts about an Indian strain a coronavirus.

 Lots of new cases a covid today is in all world is Indian variant, which WHO shared a name Delta , and he is more fashionable,than a last, and his course is on 2 times less, than in other kinds Corona, and thus he is more dangerous.

1. Variant for Delta Strain a first time found in India on latest autumn , and in his found mutation P681R, in result a which changed a small fragment S -protein, that done a virus more contagious.

2. Dangerous for delta is in high concentration virus, as a calling virus load in sinuses in patient are on 1000 times more an original. And in viruses relations using an understanding as index for reproduction, where in ability to infect. And by scientists stats, index for reproduction a delta-variant is increased on 2-2.5 times.  If before virus carrier ability attacked for 1-2 patients  till his finding a delta, thus now are till 5–6 patients.

3. And disease course is very fast, thus importance to check for diseases condition and timely doctor visiting, The Lancet shares, by researching as infectious diseases, is Delta on 2 times increasing risk for hospitalization , than in alpha.

4. Symptoms for diseases as keeping classical for COVID 19, cough, fever, smell lost, taste, but ability and differencing, as charactering  ,like in ARVD  with runny nose, headaches, ache throat or gastrointestinal with diarrhoea, sickness, nausea, as symptoms are same, like in cold, or bowel infection, that hardening for early diagnosis.

5. Peculiarities for Delta  is entering a most vulnerability category entering are young peoples, that in Wuhan s variant, where are adults in risk groups.

6. Lots of scientists are agreeing, that massive vaccination on 60 percents helps stops chains for infecting and ability preventing new strains for infection.

7. And specialists for control and centres preventing diseases in the USA /CDC/, AND NATIONAL CONSULTATIVE COMMITMENT  by immunization a Canada /NACI says, that if for the short time stopping vaccinating in massive ordering , thus are right away growing patients as for infection perceiving, and this is leading to dead, and high loading on the system for healthcare in common.

8. And on the beginning a Autumn-winter time are risks for flu infecting and worsening epidemiologic environment , thus experts for health institute and social favourable in Finland are warning about this infecting are right away with two viruses and flu and SARS-COV2, THUS a course for every disease is hard, creating a big loading on organism, and increasing complications risk and lethal results. And specialists advising doing vaccinations against both infections.

9. On July this year, results are published by American-Britain research , as group of 75 patients, that hypothesis evidences,as vaccination against flu is lowering numbers for hard cases a corona, and found, that who vaccinated against flu, is less hard results in COVID-19, as strokes and infarcts.

10. Received a second component in vaccination  are often calming, now am peoples between staying, but not forget about social distance, and mask regime, and for manufacturing a full immunity are two months needing, antibodies manufacturing for 21 days, since after first vaccination dose, and same after a second, but for a consolidation immune reaction are need still 20 days.

Hand is in trap.

 On November 2018, am stayed at hospital with diagnosis as compression ishemic  neuropathy for right median nerve of right wrist with hurt syndrome, as of result protracting   acuting  .2years ago this problem happened, but am felt hurt and cheped.At  hospital for me done injections, droppers applied, after hospital felt better, but after again hurt .In   zoz   for no  1 6, 2019 read post by Neurologist Seliverstova, that read same about neuropathy, but for hip. Asking her a question, ad help , that hot to stop hurt, four fingers on right hand hurt, and on the nighttime, small finger just works, analgesics not help, rubbing too.

A how to live?

 Pressing for median nerve of hand is calling carpal syndrome canal, as anatomic narrowing in wrist. And other calling this neuropathy kind is tunnel wrist syndrome, which very often spreading in adults. Pathology is not dead, but affecting on the wrist work, and patient later loosing ability for loosing with hand doing an simple things. And how this is happens?

    Median nerve for wrist tie with CNS of muscle, answering for targeting and opposition for big finger, bending and bending out direction phalanges and middle fingers. In decreasing sizes for wrist canal is compression having for median nerve, that leading to destroys his blood  supply, as ishemia, like entering in trap,and its true hurt.

Reasons for carpal syndrome are local pathologic processes and in tunnel region, and common systemic diseases as: sugar diabetes, hypothyreosis,as lowering thyroid gland function, ovaries functional destroys, hormonal background changing on climax stage, systemic diseases for connective tissue as rheumatoid arthritis, lupus, system scleroderma, polymyositis, gout, diseases for support-mobility apparatus.

And also leading  are big sizes forming for median nerve /neurofibroma, lipoma/.

Diagnosis here are neurologist checking, blood test on glucose level, TTH, elector  physiologic testing is electer  neuromiography for ultrasound nerves median, x ray for ray wrist canals.

And cure for tunnel syndrome depending on from a reason caused and character for local tissue changes in tunnel by ultrasound test and ENMG.For   example  a full cure for sugar diabetes or hypothyreosis are leading to damaging nerve allowing decreasing symptoms his irritation or a full avoiding his. At the same time using pathogenetical cures methods for removing loading a nerve by decreasing tissue edema or decompression nerve. And here using special items as bandages, orthosis, splint  are limiting mobility in damage region. They are comfortable in use and easy wear ,  remove, and buy theirs at pharmacy markets . And effectivity here a using for alfa-lipoid  acid as thioctic acid/octolipen, berlition, tiogamma, tioctacide. espa-lipon, one pill on 600 mg for morning on am empty stomach within month.

In finding neuropathic ache component ,keeping burning aches in wrist, are using  anticonvulsants as gabapentin, pregabalin, which prescribing by doctor s and control. If these remedies no helping in strong aches thus using a cure-diagnostic blockade in a entering in region for pinching as in carpal canal a anaesthetic novocaine, and hormone hydrocortisone. And surgery indications using  is in insufficient effect for conservative therapy and if in patients having: Signs for straight nerve compression by bone forming, fibrosis structures, scar-adhesion processes, tumor or haematoma, stable ache syndrome, lowering work ability, progressing atrophic paresis are few muscles with a lowering professional work capacity or social adaptation.And analgesics, rubbing in data diagnosis are not effectivity, as not removing a base reason a diseases is compressing nerve n wrist canal.

Seliverstova Ekaterina, neurologist M.D.