A time to collect buds.

 Waking up a bature, earth when birds are singing, ponmds and melting, thus means are nature s treasures opening.

A first spring collections are buds, theirs high riches are raisins containing, essential oils and fatty acids, they  are giving string anti-inflammatory, anti cicerone ,analgetic, anti-itching effects.As by effects'  buds are not gives in for many antibiotics' effectivity. But vital microorganisms they are as zubiotics are probiotics is miracle effects having are not killing an own normal microflora they substances for bowel. But raisins are irritating kidneys, thus with nephritis and pregnancies care using buds. A most popular are birch buds, birch is ties with history and life in Shavians, her bowed does as an importance language god. For her dedicated songs, she kept a health in peoples, healing diseases, illnesses, infirmities by an buds, leafs, and bark. Buds  collecting in Central Russia on the spring begin till theirs visible swelling, cut twigs are keeping for 4 weeks on the cold, after threshing. A most often buds using as spirit tinctures of vodka 1 to 10, keeping 3 weeks and filter, drinking in water diluting or milk, for 3 times/day on 15-20  drops in body weight on 70 kg and to 30 drops for using are for obese peoples. And its method is universal and matching for other peoples.Spirit tincture is effective remedy , and very comfortable, and always close a ready remedy, keeping of which are 5 years. Buds   birch  very strong anti-inflammatory effectivity, and high anti microbe activity in relation for big quantities  stable ,so as antibiotic-corrosion stamps for microflora as staphylococcus. Buds are antivirus effect having , stimulating producing interferon, febrifuge, and antitoxic effects, helping in any virus and cold diseases. Tincture of buds used in ulcer disease, chronic gastritis, cholera, vomiting, chronic diarrhoea, and in helminth her fearing ascarids and  pinworms, heart edemas, poor menses, hormonal regulating effecting. After birth period leading lowering to minimum a blood lost ,  and blood cleaning , healing, common strengthening. A most often buds of birch cure joints, skin diseases, and use theirs in all remedy forms, as water infusion, ointment, tinctures , of hard fusible fats or oily extracts of vegetable oils. And for extractions getting  is vegetable oil keeping on water bath on 30 min, after mix with rubbed buds on 5 to  relation parts .For  ointment getting s warming pork fat, till  colour changing .  Removing cracklings mixing with buds, after ten min warming . Our ancestors cooking ointment as on a same put by layers are birch buds and steamed for day in a not hot oven, tighter greased pot with pastry.

Squeezed through gauze , received mass rubbed in ache joints for one time before sleep. Cool in place kept, closed tighter   . But oily all preparations are faster rancider. Modern herbalists avoided theirs .  

2 stages.

 Am not agree with an mail s author: yes, in polycystic   ovaries to ability to be as  pregnancy is lowed, but its possible. And pregnancy endure, as a few womens  in a force for hormonal change in organism are not having whishes to have a baby, but if you are want , thus chances are high and favourable. And cure for sterility in polycystic   ovaries doing after investigation as a of 2 stages.As  a   first is ready, second stimulation for ovulation.Cure on the ready stage depends  from  a reason of disease. For example in obesity using diet with limiting carbohydrate till 180-200 gr, fats are   70-80 gr, ;liquid till 1.2-1.5 l. /day, and with diet using moderate physical loafs/run, swim, Scandinavian walk, skies. From the remedies for improving ovaries work prescribes   metformin on 500 mg, as 1 pill for 3 times/day for 6 months, cyclical vitamin therapy doing .On  the first phase cycle includes folic acid 1 mg 1 pill for 3 times/day, B6 vitamin on 2 mg/day intro muscular, all are  12-15 injections, on a second is vitamin C 0.5 gr for 2 times/day, B 1 2.5 mg /day intro muscular , all are 10-15 injections.

 By practise ,that body weigh lowering on 12-15 percents in women's restoring regular menses  cycle, and in 1/3 is ovulation possible ,  and possible to be a pregnancy. For regulation mense cycle are using hormones  are Norcolut, Dufaston, Utrozestan, not fear theirs after analyses and investigations doctor select individual scheme for cute and allowing for ovaries doing a right function.When   adrenal failure in polycystic  ovaries prescribing dexamethasone, prednisolone, methylprednisolone, dosages are individuality, course are 3 months. On the second stage is stimulating ovulation, clomifen is remedy for selecting.Stimulating  ovulation processes, when course are cure are 3 months, he's regulating  hormonal metabolism.If clomifen not effectivity, that adds metformin.By practise that tandem restoring regular menses cycle and restoring ovulation in 70 percents women's with Polycystic ovaries, such cure doing under doctor checking with ultrasound control. For restoring ovulation and using surgery cure, but its doing, when  data therapy not helped. But,  one minus in surgery having, that positive effect having a short character, in a first year passing for restoring ovulation lowering on the 40 percents, and in 3-5 years stopping in common.And surgery cure advising  on second queue after using remedies.

In a few forms for polycsystic   additionaly helping and herbs as orthillia secunda, rhodiola  quadrifidra, nettle root, oregano, wormwood, humulus   lupulus, birch, inula   helendium, peony, tansy, plantain, mint,  licorice, seeds of flax, and herbs cure is long till half year as 3 weeks is course, 1 week is rest. Here   need to guess, that pause in cure drooping on the menses time . A rhodiola is a strong female hormone,  and female herb, cue polycystic , restoring wrong hormonal background, and rejuvenating organism, strengthening forces, rising immunity.

2 tea.sp. of chopped roots rhodiola quadrif. Adding in glass of the hot water, cook 20 min, infuse 30 min, filter, use for 3 times/day on 1/3 glass before meal, use are three such course in menses between periods.

And care use data recipe, as in hypertension.

And effective remedies, improving hormonal background is licorice,as antibacterial, antivirus, calming, lowering cholesterol level, that importance for manufacturing testosterone are base male hormones. 

1 tbl.sp. chopped roots of licorice add in 1 glass of the hot water, keep on water bath for 15 min, infuse 1 hour, filter, use on 1/4 glass for 4 times/day.

Recipes for regulating menses cycle.

2 tbl.sp, of sage add in 2 glasses of hot water, infuse hour, use within a day , like tea.

Chopped roots of nettle, dandelion, peony, herb mint, fr. of hibiscus mix, 2 tbl.sp. of mixture  add in 3 glasses of the hot water, infuse 2 hours, filter. Use on half glass for 3 times/day not depending on from a meal time, and sweet infusion with 1-2  spoons of honey.

By L.Hodakovskaja , gynaecologist, doctor, obstetrician , high category, ultrasound diagnosis.

  

 

Russian Journal of Genetics

Pleiades Publishing

​Вы​

Contents

Russian Journal of Genetics

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Vol. 62, No. 5, 2026

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REVIEWS AND THEORETICAL ARTICLES

Stages of the Great Journey: From Primary DNA Identification of an Individual to Future DNA Registration of the Entire Population

A. V. Chemeris, R. R. Garafutdinov, D. A. Chemeris, Ya. I. Alekseev, A. R. Sakhabutdinova, R. R. Galyautdinov, A. F. Khaliullina, I. A. Makarenko, and F. G. Aminev p. 539  abstract

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MOLECULAR GENETICS

Design and Efficacy Evaluation of CRISPR/Cas9 Guide RNAs for Knockout of the Cyp21a1 Gene in Mouse Cells and Embryos

E. N. Antonova, E. E. Uldanova, A. S. Trifonova, E. D. Piven, O. V. Glazova, N. Sakr, N. V. Rudev, M. V. Vorontsova, O. N. Mityaeva, and P. Y. Volchkov p. 553  abstract

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GENETICS OF MICROORGANISMS

Transcription Repression Reverses the Expected Trend of Gene-Targeting Success in Yeast

P. T. Mitrikeski p. 563  abstract

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PLANT GENETICS

Development of Chloroplast Markers for Studying the Population Structure of Birches in the North Caucasus

I. O. Nepriakhin, V. L. Semerikov, and H. U. Aliev p. 569  abstract

Identification of Reliable Reference Genes for Gene Expression Analysis in Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao under Cold and ABA Stress

Y. Pan, Y. Yu, J. J. Chen, Z. Lv, Y.H.g Long, M. Jiang, and H. Li p. 578  abstract

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ANIMAL GENETICS

B Chromosome Variability in the Korean Field Mouse Apodemus peninsulae (Rodentia) from Zabaikalsky Krai. Communication 2. Analysis of B Chromosome Mosaicism

G. V. Roslik, I. V. Kartavtseva, M. V. Pavlenko, and Yu. A. Bazhenov p. 593  abstract

Association between SNP 2569 T>C of the MBL1 Gene and Reproductive Health in Kholmogory Cattle

I. S. Kozhevnikova, N. A. Khudyakova, A. S. Kashin, and M. S. Kalmykova p. 604  abstract

Analysis of the Gene Pools of the Altai and Novoaltai Horse Breeds in the Altai Republic

E. A. Soloshenkova, A. P. Todoshev, A. A. Onokhov, A. D. Soloshenkov, T. A. Bratchikova, V. N. Voronkova, V. I. Yntaev, and Yu. A. Stolpovsky p. 611  abstract

Analysis of the Population Genetic Structure of Anopheles kleini of the Far East of Russia Based on the Variability of the BOLD Fragment of the COI Mitochondrial Gene

B. V. Andrianov, A. G. Bega, V. I. Panov, I. I. Goryacheva, M. I. Gordeev, and A. V. Moskaev p. 624  abstract

Population-Genetic Structure of Local Sheep (Ovis aries) Breeds from Altai, Tuva, and Mongolia Based on Microsatellite Markers

G. R. Svishcheva, A. P. Todoshev, S. A. Beketov, M. T. Semina, and Yu. A. Stolpovsky p. 632  abstract

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HUMAN GENETICS

Genetic Portrait of the Dolgans of the Anabar River

S. A. Fedorova, S. S. Nakhodkin, V. N. Kharkov, V. G. Pshennikova, N. A. Barashkov, T. E. Burtseva, N. A. Skryabin, V. A. Stepanov, N. V. Malisheva, and L. S. Zamorshikova p. 644  abstract

Study on the Mechanism of PSMC6 Gene in Alzheimer’s Disease Based on circRNA-miRNA-mRNA Regulatory Network Analysis

X. Yang, D. X. Wang, X. Y. Guo, Y. W. Liu, and H. Y. Liu p. 654  abstract

---

SHORT COMMUNICATIONS

Evaluation of Genotoxicity and Antigenotoxicity of Helichrysum arenarium L. Extract In Vivo

M. N. Kurchatova, A. N. Luferov, M. A. Kondratyev, and N. A. Durnova p. 663  abstract

Evolution of Heterostyly in Fagopyrum esculentum and F. cymosum Completed after Divergence of These Species

I. N. Fesenko and N. I. Bondarev p. 668  abstract

 

Contents

Russian Journal of Genetics

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Vol. 62, No. 4, 2026

---

REVIEWS AND THEORETICAL ARTICLES

Genetic Mechanisms of Premature Ovarian Insufficiency

N. S. Pavlova, V. G. Averkova, Z. Kh. Kumykova, P. N. Tsabai, T. G. Kolpakova, and S. V. Yureneva p. 399  abstract

Analysis of Genes and Proteins of Spontaneous Maize Embryogenesis and Endospermogenesis

M. I. Chumakov p. 410  abstract

Association of IL-12B (rs3212227) and IL-23R (rs11209026) Gene Polymorphisms with Psoriasis Susceptibility: A Systematic Review and Meta-Analysis

Praveen Kumar Chandra Sekar and Ramakrishnan Veerabathiran p. 417  abstract

---

GENERAL GENETICS

Effect of Cranial Irradiation of the Brain on Molecular Genetic Indices of Mitochondrial DNA in Various Tissues In Vivo

A. V. Tochilenko, D. V. Fomina, T. P. Kalinin, E. O. Levintas, N. F. Raeva, E. V. Evdokimovsky, and S. A. Abdullaev p. 430  abstract

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MOLECULAR GENETICS

Development of a System for the Safe Insertion of Transgenes into the Genomes of Model Cell Lines and Pluripotent Stem Cells

A. V. Selezneva, A. O. Sosnovtseva, E. S. Starodubova, D. O. Antonov, V. I. Barkovskaya, and S. L. Kiselev p. 438  abstract

---

GENETICS OF MICROORGANISMS

Variability of the Structure of the Melibiose Operon and the High Pathogenicity Island in Yersinia pseudotuberculosis Strains

A. S. Sidorin, K. S. Shevchenko, L. M. Kukleva, A. V. Fedorov, Ya. M. Krasnov, G. A. Eroshenko, and V. V. Kutyrev p. 448  abstract

Genomic Analysis of Bifidobacterium adolescentis Strains Using a Catalog Functional Genes: Neurobiotic Selection Algorithm

O. V. Averina, D. A. Troshina, and V. N. Danilenko p. 461  abstract

---

PLANT GENETICS

Identification of a Locus Associated with Restoration of Male Fertility in the 9E Type CMS of Sorghum

L. A. Elkonin, A. A. Vladimirova, V. M. Panin, O. P. Kibalnik, and E. V. Belyaeva p. 467  abstract

Genomic Characterization of TGA Transcription Factors in Gossypium Unravels WGD-Driven Functional Diversification in Development and Biotic Defense

S. Liang, M. Zhu, G. Yang, Ch. Fu, Ch. Lou, Y. Wang, Zh. Lu, Yu. Luo, Y. Hu, L. Xu, Y. Wang, A. Abudurezike, Yu. Wu, and X. Nie p. 480  abstract

Chloroplast Genome Architecture of Trichosanthes kirilowii Maxim.: Structural Evolution, Repetitive Element Dynamics, and Comparative Phylogenetic Insights in Cucurbitaceae

Z. Z. Jiang, X. Y. Ge, Z. H. Yang, and R. Y. Yuan p. 494  abstract

---

ANIMAL GENETICS

B Chromosome Variability in the Korean Field Mouse Apodemus peninsulae (Rodentia) from Zabaikalsky Krai. Communication 1. B Chromosome Number Variation and Morphotype Diversity

G. V. Roslik, I. V. Kartavtseva, M. V. Pavlenko, and Yu. A. Bazhenov p. 508  abstract

Variability and Relationships of the Sculpins Gymnocanthus pistilliger, G. intermedius and G. herzensteini (Cottidae) Based on Karyological Analysis

I. N. Moreva and O. A. Radchenko p. 521  abstract

---

HUMAN GENETICS

Population Genetic Characteristics of 27 Autosomal STRs in the Moscow Residents

M. D. Skalin, A. S. Gracheva, I. G. Udina, and N. K. Yankovsky p. 529  abstract

Chances are favorable.

 On my 21 y.old in testing am heard a disappointing diagnosis as polycystic  ovaries , where pregnancy not begins, and baby to bar a child are doubtful .And  doctors nothing good advised, offered to use hormones, which are hard  for health, what i must to do?Please help.

 Declassification disease.

On 1925 y. American scienists   by Stein and Levental a first time described a female disease, which bilateral increasing ovaries  and displayed with menses stopped and high body hairiness , obesity. So as a llooked classical variant for disease is polycystic  ovaries. Meeting very often on ten percents cases from a common  numbers of gynaecologic diseases, and a one from two-sided  is declassification disease -is infertility. In norm in ovaries in women's under affecting sex hormones for month in happening cyclic changes, in result of which from a one from bubbles with egg growing faster, than other , so a displaying main ,dominant follicle.Inside   itself    having mature egg, matching for fertilization .And in the middle  in the middle menses  cycle is egg comes out from a data follicle, so beginning ovulation.After egg  going in uterine tube, where meeting with sperms, and in result on which pregnancy beginning. In polycystic  ovaries data mechanism is destroyed, dominant follicle  not grows till a needing sizes, not happens ovulation, or its happening very rare, and in result a long absence ovulation is happening cyst degeneration for ovaries, where in them having follicles , but a small, middle sizes, not affecting to give a mature egg.Thus,  a conception not happening.And reasons for these displays are much and different:from a genetical predisposition, result of complicated pregnancy and births by mum, infection diseases, stresses, adrenal activity wrong, pancreas gland, structures of head brain.

A hairs  are in growth.

A beginning  for polycystic  ovaries is tied with menses beginning, and a most often displays are menses wrong and cycle, as they are absence, rare, or abundant till bleedings. And in a year and more displaying hirsutism are hairs growing by male type, as over top lip growing, around nipples, by central belly line, till hairs on the face, hips, belly. Other signs for masculinizations are narrow sizes of pelvis, increasing sizes for hands, legs with a width breast cell. And other displays: obesity, seborrhoea, acne, vegeto-vessel system destroys, thirst, insomnia, emotional not stability, glucose level rising in blood till sugar diabetes.A   put right diagnosis are good investigating, with biochemical blood test, ultrasound organs for small pelvis, and for exception a tumor  and MRT, KT for adrenals, hormonal investigation.

  

Porridge by Kursk.

 My grandma all life lived in village Samodurovks under Kursk, today her name is Igashevo  village as by a hero for Soviet Union dead in fight on the Kursk Arc. All summer am lived here, and today my remembers of big fields with buckwheat, around village is, like  ocean with thick juicy-green leafs with light small flowers  on top.  Grandma cooked a very taste buckwheat porridge in iron pots, which entered by grab in Russian oven. When  my mum, is here daughter taken grandmother in our home in town, she cooked porridge on our oven, but porridge got is too  taste. Now am cooking her porridge by her recipe .On  an  oven put 2 l. a pot with water , when she is boiling adding in deep plate 2 not a full glasses of buckwheat ,scald   her a hot water, filtering. After this a buckwheat slowly adding , mixing by spoon in boiling water in pot .By   a    taste adding salt, a few pieces of sugar, and ass a not full glass of milk. Porridge cooking with an opening lid on weak fire for 20-25 min, mixing periodically, against burning. Turn off fire, close pot with lid. Infuse her 5 min, after put a porridge portion in plate, cooling and its  an  importance, a how my grandma done a sprinkle on top are 3 tbl.sp. of fresh curd , not mixing. Taste buckwheat porridge ,which cooked my grandma and called  is by Kursk,   is ready! 

Cure complements are herbs.

 When feeling normalizing in dermatomyositis, for restoring muscles, forces of extremities and manufacturing joints, a beginning doing healing exercises, she is needing for avoiding contractures complexes of exercises prescribing Methodist by your clinical displays. A diseases and data diseases and age. And also adding gymnastic of breathing muscle, for improving lungs'  ventilation, at home you can do self-massage, as very care, not injuring muscles using strokes, rubbings, kneading for damages parts, after slightly beating. And benefit add herbs with diuretic effects. As in dermatomyositis  having face edemas with muscles inflammations, extremities, without a worries use bear berry , leafs of lingonberry, leafs, birch , buds of birch, and these are recipes:1-2 tbl.sp. of chopped leafs lingonberry , 0.5 l. of water, boil 15 min on weak fire, filter, its daily dose, use for 4 times/day before meal.

Bear berry cook in thermos of 1 tbl.sp . Mass in glass of water hot, use for a day by small portions.

2 tbl.sp. of leafs birch add 0.5 l. of the hot water, infuse, use 0.5 glass before meal, for 3 times/day. Birch buds 2 tea.sp. in 1 glass of the hot water, infuse in thermos, use for day for 3 receptions before a meal 30 min.

 Oats infusion too benefit,as 2 glasses of oats ass in 6 glasses of milk, boil, keep on a weak fire a few min, infuse, filter, use 1 glass for 3 times/day.

 Of herbs cook infusions and ointments for compresses, apply on damage parts.

Infusion for compress cook of buds, leafs of willow herb, Althea OF 1 tbl.sp. mass add in glass of the hot water, infuse for hour, filter,wet cotton fabric by size matching and apply compress.

Of chelidonius ointment.

 Chopped dried herbs add in Vaseline, as one to 4, keep in refrigerator, before every use good to mix, after 3 weeks a using doing rest.

Or pharmacy ointment using of chelidonius base and of herb toadflax. These  advices are additional, and not cancelling base cure, affecting for decreasing symptoms.

 

 

Rate symptoms are right.

  Clear clinical picture allowing right away diagnosis dermatomyositis.But same displays of muscle pathology are having in other autoimmune disease, as in adults, as  paraneoplastic dermatomyosis.

For confirm in  diagnosis using laboratory stats of a few muscle ferments and antibodies raws, specific for dermatomyositis , and prescribing other tests   too. After a reading, that everybody not wondering ,that a such hard disease needing curing at hospital with a selecting corticosteroids dosages and cytotoxic. They  are widened using in autoimmune diseases , as tied with skin diseases, joints and other organs.  Remedies prescribing on high dosages, thus  ,  additionally  using calcium remedies and vitamin D. A first dermatomyositis an awesome affecting for curing, and on a first week decreasing edemad , redness, muscle weakness, lowering laboratory stats of activity processes. Thus, importance not wait , and visit doctor, that you can to have forces visit hospital, and future disease development leading to immobilization . Thus.  am stopped on a most detailed on an all displays, but if voice horse happened of a cold drink, and heaviness in hands, legs of hard work in garden, thus its other anamnesis , but if its happened suddenly and without stopping, reasons, keeping  straining you. .  Therefore,  trying rating an own condition right as and questionable symptoms.  

When hand not holds a cup.

 Nina wrote to use , that on the last time weak, are bad hearing hands, rising hard theirs, on the skin having brown spots.

 Dermatologist shared, its a dermatomyositis, but he is not cures this disease, needing visiting rheumatologist. Maybe vestnik in specialists will share what is it?

Muscles are not controlling. 

Weak, disobedience muscles are having in many diseases and conditions, but a most serious reason is dermatomyosytis . Its systemics autoimmune disease with skin damage as dermal  and muscles myositis, women's having  on two times more, that in men, meeting and in children's.

Reasons are not knew till an end, but predispositioned are viruses role of herpes virus, rubella, bacterias, and genetical factors. Provoking a disease are over cooling, stress, long staying on the sun.

Acute disease beginning with rising temperature till 38-39C, sweating high, loosing in weight, hand rising hard, leg, to sit. After  is a not ability to walk by steps, entering in bus, car, hold a cup, stand up from bed, wearing  is processing weak faster limiting active moves. A skin signs are edemas of face, around eyes, with blue shdow, so as are glasses syndrome, skin redness on an opening body parts, are face, neck, surface external hands, over joints wrists, front of legs.Skin cover is rough with cracks, with a dark brown spots or discolouring, these changes combining with edema of pharynx, throat, voice ligaments, stomatitis, conjunctivitis.

 And a base hardens in disease is in myositis as all muscles groups, shoulder, pelvis, neck, spine, throat, gullet . If in pathology involved muscles of throat thus voice is hoarseness of voice with nose shadow, in swallowing muscles damaging is having choking.A meal is hard and liquid entering in trachea risk and very dangerous, leading to asphyxia. In damaging muscles of neck is hard to rise head from a pillow, hold her in such position. And next for future are tension contractures having and muscles calcinating of under skin cellulose ,that characterizing for child's polymyositis . Under skin calcinates can be expressing, accessing, rare inflaming joints, in a base destroying his function of contracture. Inflammation of  intercostal muscles and diaphragm destroying breathing function, lowering a vital size of lungs, affecting on pneumonia displaying. Suffering and other inside organs as gastric, and on hard case disease complicating by myocarditis and pericarditis, kidneys damaging.In weak sphincter is having involuntary urination, defecation. 

 

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