Rised insulin level stimulates special protection cells, calling macrophages , in blood vessels to fat accumulation.

That to swallow parts of fats, these parts must be a damage/glycine/ or acidified-are damages, which tied with insulin resistance, chronic stress, sleep failure and insufficient physical activity. And on a true, not need to low or isolate, remove healthy, not damaged cholesterol, which needing for organism for his functioning. When macrophages accumulating damage fat, they are turning to foam cells. Foam cells are base component for atherosclerotic plaques, they are not just having a base part of plaques, but affecting for developing atherosclerosis for a calculation an aggressive secretion of anti inflamed toxins.

 Researches are shown, that insulin increasing absorbing by macrophages are acidifying/damages/ LDL  are on 80 perc and causing almost threefold increasing of absorbing of lipids by macrophages.These  calls and aggravates damages for vessels. 

Note!

And in data case we are looking are exclusively changes of lipid profile and theirs tie with a cardiovascular disease /CVD/ IN patients with insulin resistance, but a how you are informed, many peoples in any level a insulin resistance or on a way to this. Today, are lots of debates having would a raised common and bad cholesterol or LDL , FACTOR OF RISK  for CVD and how its affecting on a common dead. A lot of researches are tie raised level of LDL WITH a raised risk for CVD  or dead, but other researches are rejected it.  A famous Danish doctor and scientist Ravnskof , a one from scientist is not thinking,that cholesterol LDL  is a reason for CVD  and think, that problem hide in other mechanisms, causing atherosclerosis and thrombosis, which leading to infarcts of myocard and other hard complications of CVD. Also in his works by science, he as many times directed ,that scientists manipulating by received stats. Thus, cholesterol is a not fault for CVD  , but tied with a chronic inflammation, as vessel, which having in peoples with insulin resistance. That means, that  dysmetabolism of cholesterol are consequences of chronic insulin resistance. And remind you, that using statins and other same remedies for a lowering high cholesterol are not allowed for metabolically healthy peoples , which are using low carbohydrate diet as healthy meal and with a normal level metabolic markers, but except a common cholesterol so as a bad cholesterol LDL  .In such peoples, a not need to cure a high level of cholesterol.