Cardiovascular diseases/CVD/.

 These are base reason for dead in all world. By WHO rates every year against CVD  deads are 18.5 million peoples, and on 2023 on the percentage are tied with them are diseases are shared on 33 perc of all deads in a world.By WHO RATES to 2023 y.from CVD will die are more 23 millions peoples  /year. A most spreading kinds for CVD  are high blood pressure, ischaemic heart disease/damage for coronary arteries of heart/, stroke, cerebrovascular diseases and rheumatic heart defect.

 On now times of mechanisms insulin resistance, affecting on development  CVD  , entering a chronic rising glucose in blood, disbalance for lipid fractions a blood, dysfunction of mucus membranes vessels/dysfunction of endothelium of vessels of lowering manufacturing oxygen nitrogen NO/, RISING REACTIVE KINDS OF OXYGEN AND BAD AFFECTING OF CHRONIC INFLAMMATION. And INCREASING LIVER GLYCOGENESIS AND LOWERING SYNTHESIS GLYCOGEN IN INSULIN RESISTANCE LEADING TO RISING LEVEL OF GLUCOSE ON AN EMPTINESS, OR HYPERGLYCAEMIA,WHICH RISES LEVEL OF COMMON Triglycerides ,   AND ARTERIAL PRESSURE, LOWERING LEVEL OF GOOD CHOLESTEROL, OR CHOLESTEROL HDL , AND RISES RISK FOR THROMBUS FORMING. Also , are stats by a long checked for patients with diabetes 1-2 types are confirmed,that hyperglycaemia , or constant rising level of glucose in blood is being importance factor for risk development  CVD. Insulin resistance lead to accumulation of visceral fat, and damages fatty cells are secreting toxic substances,which damaging blood vessels and heart structure. Thus,  fearing here needing not a high level of glucose in blood as a such, but caused by their cardiovascular diseases, which threating   for many of us and not just on adult,but more often on young ages.  An insulin resistance is base factor ,affecting on rising blood pressure, that he is affecting on natrium canals in kidneys, which delaying liquid in organism.Chronic rising level of insulin, in insulin resistance displaying ,affecting on a chronic adrenalin emission and activation of sympathy nerve system,that leading to activation of  cardiovascular system, including narrowing blood vessels in all body. Insulin resistance causing dyslipidemia as disbalance fats, including cholesterol. Characterizing a rising common level of  cholesterol, lipoproteins of low density/LPLD/ or bad cholesterol, and triglycerides in blood serum ,and lowering level of LIPOPROTEIN OF HIGH DENSITY/LPHD/ ,that in totally increasing frequency for displaying cardiovascular diseases on 32 perc. In males, and on 76 perc. in women's .

 A m sure you are understood,that high cholesterol level is a consequence of insulin resistance and caused her low level chronic inflammation of an all organism, or more   exactly a part of evolution protection mechanism, which must  protect us from such inflammation.