Insulin resistance lead to compensatory hiperinsulinemia, which stimulates transcription a gene GmRh, that increases impulse secretion for luteinizing hormone/LG/ ,

and thereby rising synthesis of male sex hormones/androgens/ in ovaries. Abundant of  androgens leading often to aggravating  fat depositing in peritoneum cavity,that enhanced inflammation and insulin resistance, continues a vicious circle. In addition, a straight intervention in insulin work , androgens ability causes are fats splitting /lipolysis/ and increase quantities for free radicals, circulating in organism, a causing insulin resistance.

Also androgens decreasing quantities of muscles tissues of first type or slow , which are having high sensitiveness to insulin, and acidifying effects , and increasing quantities of muscles tissues of second type or fat, which are being lipolitical and less sensitiveness to insulin ,that affecting on development insulin resistance in SPO. And in obesity without in women's with SPO in blood rising level of inflammatory substances/TNF, IL-18, C reactive protein.

Thus, all these stats are evidencing ,that insulin resistance and hyperandrogenemia stimulating of each other in non stopping vicious circle in SPO. Thus, SPO And his metabolic destroys are needing looking on a most wide contest of female health, and not just sterility problem.  And in common, insulin resistance and obesity   playing key role in women's with SPO and following metabolic complications. Deciding these problems is will be importance therapeutic approach for an effective lowering, not just a frequency for SPO , but other metabolic diseases, describing in this book. And am a note, that in case with SPO preparations using for curing diabetes of second type, are decreasing symptoms in SPO, and causing importance changes as positive on physiologic and biochemical level , affecting on mechanism are pathologic changes,that still emphasizing a tie between abundant using carbohydrates and development SPO.

Its proven, that a right created low carbohydrate meal, as keto diet lows insulin resistance and inflammation and affecting on weight lowering . A lowering using carbohydrates   improving sensitiveness to insulin, and following lowering chronically raised level of insulin will decrease inflammation and signal signals of ovaries, which are on against case increasing manufacturing androgens. Ketones are beta-hydroxybutyrate/BOHB/ ,which organism begins manufacturing from a fat in answer on limiting base carbohydrates, are not just using by cells as for fuel source, and having antioxidant effect. Researches are showing , that BOHB also lowering activity of key gene, controlling a inflammation and giving multi-level  approach to inflammation suppressing.As a so ache menses  and inflammation going as hand about hand, lowering chronic inflammation with a right meal, will improve life quality in women's, and not to say and about fertility. And two big researches are shown , that right selected keto-diet will improve hormonal b profile in women's with SPO and rise theirs chances to be a pregnancy.