Syndrome of polycystic ovaries/SPO/.

 SPO  is endrocrine-metabolic diseasem characterizing a width spectrum of hormonal destroys, mirror reflecting a clinical displays og hyperandrogenism, and damaging 5-10 perc. of womens by reproductive system.

 Diagnostical criterias for SPO are not unified, these are a few phenotypes of SPO Having, but women's  with SPO having are two from these base signs:

Abundant androgens , that displaying of increasing hairs quantities on a body, or theirs darkening.

Chronic an oligo -or an ovulation   with absence menses or non-regular of menses cycle.

SPO by ultrasound checking having.

 These all symptoms  are caused by a both common components of many metabolic diseases  by insulin resistance and inflammation. But insulin resistance and inflammation are not entering in official diagnosis criteria, they are tied with SPO symptoms, and with SPO associations with other metabolic diseases,as diabetes 2 nd type, obesity, dyslipidemia, not alcohol fatty disease of liver and high blood pressure. And not depending on from index body mass /IBM/ , are lots of women's with SPO having a level of insulin resistance:

 

Researches are showing, that insulin resistance and destroyed tolerance to glucose are meeting in 44-70 perc. of women's with SPO .

In compares with womens without SPO  , and in women's with SPO are on 2-4 times risk for development pre-diabetes and diabetes of 2 nd type, gestation diabetes and obesity. These metabolic destroys are affecting on cardiovascular complications' development, and obesity, and cancer of endometrium. And development for SPO affecting of rising level of insulin, and glucose in blood, and encasement for acidifying stress, that characterising for dysregulation insulin.  A how happens dysregulation of insulin in this syndrome is not found till end, but probably tied with destroyed signal function of insulin or receptors, that  leading to rising secretion of insulin, and slowing down liver clearance insulin/as over manufacturing insulin.