Alzheimer disease.

 Alzheimer disease/AD/  IS progressing neurodegenerative disease as a sixth reason base for dead in the USA , as on 65 y.old and older, but disease is getting younger. Recently epidemiologic researches are shown, that insulin resistance rising risk for AD  and tied with her dementia.AD  is specific for brain a diabetes form, characterizing a destroyed glucose transport and energy balance and chronic inflammation. Researches are shown, that insulin reception having in all cells of brain, thus insulin signalization playing importance role and different in brain functioning and development AD. Insulin resistance of brain is not ability for cells of brain reacting on the normal or rising insulin quantity in conditions of chronic abundant carbohydrates using. Also, a last stats shown,that in obesity a inflammation of fatty tissue as a such, but especially are fatty parts of glucose addicted lipoproteins/cholesterol in fatty acid plays role in development AD. Potential target of inflammation caused a insulin resistance  is well-known apolipoprotein E/ApoE/ ,WHICH NOW IS A SUBJECT FOR MANY RESEARCHES AND HIS POTENTIAL AFFECTING ON DISPLAYING AND DEVELOPMENT OF DEMENTIA. Many genetical tests offering a finding this gene staying ,that a risk for to sick of dementia. Chronic inflammation affecting for manufacturing other anti-inflammatory mediators including TNF-A,il-6, il-1B, AND a most importance these mediators among is IL-6 /INTERLEUKIN -6/, which stimulates forming protein-predecessor amyloid APP AND OFTEN FINDING IN BRAIN IN PATIENTS WITH AD disease with depositing AB AS BETA-AMYLOID . Therefore , insulin resistance affecting on displaying and development AD BY A FEW WAYS.

Many researches are confirming a positive effect  of statins on brain, that ability prevents dementia. But,  stats are having, that are using patients with obesity and diabetes of second type are potentially rising risk for development of dementia and aggravate are still had dementia.