Immunity as friend or enemy.

 As reading zoz, our readers meeting with controversy for each other  phrases as immunity protects, immunity attacks, lowering immunity... strengthening immune system, immune globulins, antibodies, cytokines, what is calling, is hard sorting out, and on a pandemic today this is importance to know.

And our immune system built hard and on a simple words as immunity having as inborn, and adaptive /acquired. As with inborn immunity as ability to protect organism against infections a human was born . As this is base setting.And in organism growing he meeting with an other more widen bacterias around, viruses, infection agents and thus immunity learning working as sighting, killing pathogens. And such forming adaptive immunity,and thanks for ability this immune system are vaccinations working,as training organism to the meet with a future infection,thus in vaccinated peoples disease is a not development or easy displaying.

And in both immunities  are two bases as humoral and cellular chain.Humoral immunity showing with protein structures  are immune globulins and systemic complement, which circulates in blood current, entering in infected tissues and helping for organism fighting with a different infections.And immune globulins as attuned against concrete target as antigen and calling antibodies. And usually such targets parts for nucleases virus or bacteria, toxins, and other foreign elements. And in autoimmune diseases in immune system happening failure by recognizing as and own and and foreign and thus immunity aggression showing to an own healthy  cells and tissues,and in result of such wrong work in organism manufacturing antibodies, directing against elements of an own tissues and organs. And to the typical autoimmune disease is having thyreoditis Hashimoto , lupus, diabetes first type, and all autoimmune diseases in country are having till 80 diseases. A cellular immunity having with lots of leucocytes as white blood cells,which swimming in blood and soldiers for our immune system. And a base players for command the adaptive cellular immunity are T lymphocytes and B lymphocytes.

And in development autoimmune diseases a base role directing for B lymphocytes,as they are manufacturing antibodies, which are in aggression immune system,like of sighting bombing are directing on a certain Structures of tissues,causing damages with a following destroying theirs function. And certaining different autoantibodies in blood playing importance role for diagnosis putting.

As killing factories for autoantibodies as B lymphocytes is a one method curing a few diseases as rheumatoid arthritis, vasculitis kinds. And an own negative role in development inflammation in autoimmune diseases playing protein structures as calling pro-inflammatory cytokines.  Damaging different organs, tissues ,they are secreting by different cells and uniting forming cytokine storm is fasting inflammation reaction is dangerous for organism,  but within a years are manufactured gene engineering biologic preparations as blocking cytokines and stopping inflammation.

And about immunity strengthening.  A such remedy not manufactured today,which would be work,and individual remedy,which additionally protect our organism against infection  are human s immunoglobulins. And his using in inborn or adaptive receiving deficit an own immunoglobulins and of injections. And this is serious remedy and costs very high and use in a very weighty indications. And usual immune modulates and immune stimulants serious effect on immune system are not influencing and for patients with autoimmune diseases they are very dangerous because of an own peculiarities to provoke a disease. And when patients asking me a how to strengthen immunity am advising a very simple as use sport, but not till fanatic, balancing eating as with a proteins rich, vitamins, avoid bad habits, more stay on fresh air, and more move, move!

By Smitienko , rheumatologist, M.D.