Contents

Molecular Biology

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Vol. 60, No. 5, 2026

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REVIEWS

SPATIAL TRANSCRIPTOMICS FOR MOLECULAR DISSECTING OF THE TUMOR IMMUNE MICROENVIRONMENT: COMPARISON OF COMMERCIALLY AVAILABLE PLATFORMS

I. V. Larionova, E. O. Shmakova, P. S. Iamshchikov, S. A. Iamshchikova, N. V. Cherdyntseva, and J. Kzhyshkowska p. 617  abstract

Modern Models of Breast Cancer: Integration of Molecular Biological Approaches for Study of Signaling Pathways and Development of Therapies

A. S. Kadyrova, A. A. Rizvanov, and V. V. Solovyeva p. 640  abstract

Production of AAV Vectors in a Baculovirus Expression System: A Review of Technologies and Approaches

O. V. Orlova, D. V. Glazkova, O. N. Sidorova, G. A. Shipulin, and E. V. Bogoslovskaya p. 669  abstract

Genes of Growth Factors and Neurotrophins as Promising Therapeutic Transgenes for Gene and Cell Therapy of Neurodegenerative Diseases

V. S. Shishkina, V. Yu. Pokidko, A. I. Mukhina, A. D. Voronova, E. K. Karsuntseva, G. A. Fursa, A. V. Chadin, V. P. Masenko, O. V. Stepanova, and V. P. Chekhonin p. 684  abstract

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GENOMICS. TRANSCRIPTOMICS

In silico Identification of miR-16 Family Target Genes and Pathways Involved in Osteosarcoma Chemoresistance

W. Y. Xue, Y. Z. Wang, R. N. Chuprov-Netochin, M. V. Pustovalova, D. V. Kuzmin, and S. V. Leonov p. 696  abstract

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CELL MOLECULAR BIOLOGY

Vitamin D Exerts Anti-Inflammatory Effects by M1 Macrophages in an Inflammatory Environment of Lung Cells

H. Zhen, Q. Wei, B. Wei, M. Liang, Q. Huang, and R. Li p. 710  abstract

Ribosomal Protein RACK1 as a Potential Substrate of PKR Protein Kinase: In Vitro Analysis

A. V. Shuvalov, N. S. Bizyaev, K. S. Evmenov, E. Z. Alkalaeva, and P. M. Kolosov p. 719  abstract

Leukocyte Telomere Length as a Marker for Differentiating Carcinoma in Situ of the Bladder from Non-Carcinoma In Situ Bladder Tumors

G. Güllü Amuran, I. Peker Eyüboğlu, B. Polat, Y. E. Genç, H. B. Akay, H. K. Çam, and M. Akkiprik p. 727  abstract

NRP1 Promotes Chronic Lymphocytic Leukemia Progression by Regulating Lipid Synthesis via the EGFR/Akt/SREBP-1 Pathway

F. Jia and K. Xiang p. 738  abstract

Inhibition of the NF-κB Signaling Pathway Mediates the Anti-Inflammatory Effect of Ursolic Acid on LPS-Stimulated Oral Squamous Cell Carcinoma Cells

X. Yao, J. Lei, L. Nie, Y. Li, J. Zhong, and D. Wang p. 750  abstract

Analysis of RACK1 Redistribution and Phosphorylation in Cortical Neuron Compartments in Response to NMDA Receptor Activation

P. A. Fortygina, N. V. Bal, E. Z. Alkalaeva, and P. M. Kolosov p. 763  abstract

Genome-Wide Identification of Alternative Splicing and RNA-Binding Proteins Regulators Respond to Glutamine Therapy for Acute Kidney Injury

Sh. Wang, H. Chen, W. Maierziya, Sh. Wang, S. Ba, Y. Li, L. Zhang, G. Zhu, and C. Lu p. 771  abstract

Effect of HSP70 and Hydrogen Sulfide Donor on Activation of THP-1 Cells by Various Allergens

M. M. Yurinskaya, O. G. Zatsepina, V. Yu. Shilova, D. G. Garbuz, M. B. Evgen’ev, and M. G. Vinokurov p. 786  abstract

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STRUCTURAL-FUNCTIONAL ANALYSIS OF BIOPOLYMERS AND THEIR COMPLEXES

Redox-Dependent Isoforms of the Bacillus cereus Fur Protein: Identification, Structural and Functional Analysis

V. I. Salyamov, O. S. Kostareva, S. G. Mayorov, S. V. Tishchenko, A. G. Gabdulkhakov, A. S. Nagel, Z. I. Andreeva-Kovalevskaya, A. V. Siunov, and A. S. Solonin p. 800  abstract

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BIOINFORMATICS

Epigenetic Reactivation of F9 via HNF4α as a Therapeutic Strategy for Hemophilia B

Y. Alyahyawi and T. M. Belali p. 814  abstract

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PROTEOMICS

Proteomics Analysis of Purified Murine Renal Lipid Droplets

W. Y. Wang, X. M. Ma, X. Y. Meng, and H. C. Wang p. 825  abstract

In the different allergy displaying a healig meal having a few peculiarities.

 An importance in urticaria, diet entering just not artificial food ,canned, salicylates, tartarize, benzoates, sulphide  are using in meal s manufacturing, avoiding eating food with B550-553, E102, E110, E122-124, E127, E151, E220-227, E249-252, E210-219, E321. In acuting allergy for the first 2 days using starving, as drinking tea weak, water, after slowly entering in ration dates  anti alley meals. Are porridges, soups  of meat, cereals, vegetables, rusks, whole cereal bread, when symptoms are weak, using other allowed products.

Elimination diets.

Avoiding dishes, which a having high sensitive, crossed allergens. As for preventing prescribing  elimination diets, when allergy signs having for year, such meal regime is keeping constantly. In season diseases using diet as when are herbs blooming -allergens. A diet keeping as depending on  from an acuting her,  in allergy on milk cow, fish these products are expecting for a many years, for other meal her limiting  for weeks or months and it's  enough. An  exception period defining by a having in blood antibodies specific. And sometimes a finding last, that meaning a high sensitiveness, but symptoms of diseases are not having. In allergy on the cow milk, avoiding a meal with cow milk, as a dry milk if also having , milk whey, butter oil, curd, ice cream, casein, margarine, lactose , cheeses.On eggs  allergy from ration avoiding any dishes with eggs, also egg powder, albumin. And in allergy on the pollen of trees avoiding eating cherry sweet, apricots, peaches, nuts. Avoiding eating red apples, honey, strawberry , young potato, drink birch juice. And avoiding using vegetable remedies as alder cones or birch buds. And in contact with cereals herbs, in allergy on pollen are avoiding honey, millet as beer, millet vodka, whisky, meal dishes with dressings. In allergy on pollen of weeds avoiding eating honey, sunflower oil, celery, peaches, melon, watermelons, not drink mixtures with field herbs. And doctor will help you in selecting remedies also, and will control you, as remedies using,diet will create therapy is most effective. 

Diet in allergy for adult.

 Is an importance cure component, and base  for avoiding meal eating are products ,which leading to symptoms developing or theirs rising.And cure having are individual peculiarise , and depending  as would allergen know or not.

Principles for diet therapy.

A diet here ability in not special, when a needing decreasing loading on organism, her using is reason for allergy not known, and prescribing, that avoiding acuing her base diseases as asthma. If allergy formed and food known, which on she's displaying, thus using elimination diets, and here avoiding just a such meal, which causing reactions of high sensitiveness. And to find substances ,which leading to allergy displaying, use meal s diary, where writing stats, info about meal, which you are eating. Add dates, and date for eating, dishes names, dates for keeping meal, and methods for cooking, manufacturing, signs of displaying allergy reactions and theirs expression. Diary use for 1-2 month.And on this time keep non-specific hypo-allergen diet, and avoiding meal, which caused allergy, and on this time ,when you are using diary,not using antihistamines, glucocorticosteroids as local by, inside. One time/week consulting with your doctor, a last to analyse received from diary information, and give advice.

Raws of products are excepting from ration.

Citric, are lemons, grapefruits, oranges, mandarins.

Spices are ketchup, mustard, vinegar, different dressings.

Smoked meal, and with canned.

Spicy cheeses, spreading for.

Eggs, mushrooms, nuts, honey, chocolate, pineapple, watermelon, strawberry, fragaria vesca, grape and orange, red fruits, berries.

Pastry meal , yeast.

Caramel, pastille, zephyr, tomatoes, red pepper, aubergines, radish red, white, sorrel, spinach, fat bird, bird dishes, fish, sea meal, salted, fish dishes, broths, caviar and etc.

Caffeine,  any alcohol drink, fruit,gas drinks, chewing gum, artificial meal.

Non-specific hypo-allergen diet.

 A full value meal, lowering allergy displaying. Energy value 2800 kcal, as in 200 gr of carbohydrates, 150n gr of fats, 15 gr of proteins, and enough vitamins quantities having.

Products allowing eating, but on the small quantities.

Macaronis, flour high sorts of made bread , garlic, onion, butter oil, whole milk, just in dishes, but yogurt with fruits adding.

Allowing eating.

Not fat boiled meat, bird, better select a rabbit, veal, turkey, cereal soups or vegetable, as vegetarian, or of fresh broth, sunflower, olive oil  boiled potato, porridges as rice, oats, buckwheat, fresh cucumbers, dill, petroselinum.

Milk, sour milk as by 1 day, are rjazenka, sour milk, natural bio yogurts without additions, curd, white rennet cheeses, baked apples, sugar, tea, whole cereal bread and crispbread, compotes of dried fruits, not of raisin and apples.

 

yoga and point massage against allergy.

### Page 1 - YOGA FOR ALLERGIES (p. 26)

Currently, about 30-40% of the Earth's population suffers from allergies. Every decade the incidence of allergic diseases increases, and in all countries it is leveling out. Over the past few years, the most optimistic predictions of doctors have not been justified in terms of improving the situation in this direction. In such a situation, prevention is very important. Yoga suggests doing special asanas at home, which comprehensively affect the body and alleviate the condition in case of allergy.

**JATHARA PARIVARTANASANA**

**(Internal abdominal massage)**

**Technique:**

Lie on your back on the floor.

Extend your arms out to the sides at shoulder line so that the body resembles a cross.

Exhale, raise both legs together to a vertical position. The legs should be held perpendicular to the floor. Do not bend the legs at the knees, keep them straight as rods.

In this position, take several inhales and exhales.

Exhale, hold your breath and move both legs together to the left and down to the floor until the toes of the left foot touch the fingertips of the left hand. Try not to touch the right shoulder to the floor. The left shoulder should not lift off the floor. If it is difficult to perform, you can hold onto the floor with your right hand behind any support.

Make sure both legs are lowered together, knees should be tense. The lumbar part of the spine should be straight during the exercise, do not turn the pelvis on the floor — up if possible.

All movements are very slow, the slower the movement, the stronger its effect on the abdominal cavity. If only the legs are trained in the abdominal cavity, then stay in this pose for about 20 seconds.

Stay in this position for a while, keeping your legs tense, then return them to the vertical position.

Stay in this pose for some time, take several breaths in and out, and then repeat the movement, lowering the legs to the right. Stay in this pose for the same amount of time, then return the legs to the vertical position and, finally, lower them to the floor. Relax.

**PRASARITA PADOTTANASANA**

**Technique:**

Stand straight, with your feet together so that the heels and big toes touch each other. Tighten your knees, pull up the kneecaps, tighten the upper thighs and lift the abdominal muscles. Pull your stomach in, chest forward, spine pulled up, neck straight. Body weight should be distributed between the heels and toes.

Inhale, place the hands on the waist (fingers should be pointing forward) and spread the legs as wide as possible (130-150 cm) and bend back.

Tighten the legs, pulling up the kneecaps.

Exhale and place your palms on the floor in line with the shoulders and shoulder-width apart.

Inhale and lift your head up, arching your back. Stay in this position for 10-15 seconds, breathing normally.

Exhale, bend your arms at the elbows and touch the crown of your head to the floor, while trying not to bend your legs at the knees. Body weight should not be transferred to the head. Support should be on both feet, both palms and the head. Stay in this position...

[Top right fragment, continuation of next pose:]

...touch the crown of your head to the floor, you can move your palms slightly forward. But the head must be kept on the same line with the feet.

### Page 2 - Continuation

Inhale, raise your head off the floor and straighten your arms at the elbows. Keep your head high, arch your back, this is the beginning of the exercise.

Inhale and lift your torso to a vertical position.

Exhale and with a jump return to the starting position.

**UDARA AKARSHANASANA**

**(Abdominal contraction pose)**

**Technique:**

Stand straight, placing your feet about 30 cm apart (feet should be parallel to each other).

Squat down, place your palms on your knees.

Exhale. Touch the left knee to the floor in front of the right foot, turning the torso and head to the right as much as possible. Press the right knee to the stomach, pressing the right thigh against the stomach. Turn the head back to the left - as if trying to look behind you, to increase the twisting of the torso and pressure on the stomach.

Hold the pose for a few seconds while the pause lasts after exhaling. Inhale and return to the starting position.

Repeat the exercise to the other side, changing the position of the legs. Press the right knee to the floor, and the left knee - to the stomach, turning the head to the left.

Repeat the exercise on both sides 4 times.

Pay special attention to starting with turning the torso to the left, as it is this variant that promotes the correct movement of the contents of the large intestine.

To get the maximum positive result, yoga exercises should be done not only during the period of allergy exacerbation, but all year round.**TIPS FOR YOGA PRACTICE**

1. Practice at your own pace. If you are tired and need to take a break, stop and rest.

2. If in a certain pose you cannot reach, for example, your toes, do not torment yourself. You can harm yourself if you do not stop trying to do what your ligaments are not capable of. Get to the place you can reach, or ask the trainer for a simpler replacement exercise.

3. Train in comfortable yoga clothes. It should hug your body, but not to attract excessive attention, but so that the trainer can see what form you are in and how you perform the exercises.

4. Throw any doubts out of your head and just try yoga. Be open to new experiences, especially since yoga does not require special preparation or physical fitness from you.

5. Do not strain during asanas that require good stretching, just relax, let go of your ligaments and try to get pleasure from it.

**HOW TO BREATHE CORRECTLY DURING PHYSICAL EXERCISES**

Breathing plays a very important role in yoga classes. Everything is tied to it. There are several options for relaxing with the help of breathing.

1. **Sama Vritti**, or "equal breathing". This is breathing in which the inhalation is equal in duration to the exhalation. This breathing style calms the nervous system, lowers blood pressure and relieves stress.

2. **Ujjayi** (victorious spirit). During this breathing you will make a slightly hissing sound (almost like Darth Vader). During this breathing you do inhalation and exhalation through the nose, slightly squeezing the glottis.

**What not to do?** When it comes to poses in which it is difficult to maintain balance or stand for a long time, we usually start to hold our breath. This should not be done in any case. Just take it as a sign of your fatigue and take a short break.

In yoga there are a huge number of different breathing practices, and if you have chosen a good instructor, he will definitely tell you how to do it correctly. Just remember that holding your breath while doing exercises, if the trainer does not say so, is not allowed.

### Page 3 - ACUPRESSURE MASSAGE FOR ALLERGIES (p. 24)

For allergies, the following group of points is acted upon (picture 1).

**Point 1.** Asymmetrical, located on the posterior midline between the spinous processes of the VII cervical and I thoracic vertebrae. The patient sits, tilting the head forward. The point is massaged with the middle finger. Duration of exposure to the point — up to 10 minutes.

**Point 2.** Symmetrical, located 1.5 cun to the side from the posterior midline, at the level of the gap between the spinous processes of the III and IV thoracic vertebrae. The patient lies on the stomach or sits, tilting forward. The point is massaged simultaneously on both sides.

**Point 3.** Symmetrical, located 1.5 cun to the side from the posterior midline at the level of the gap between the spinous processes of the VII and VIII thoracic vertebrae. Massaged as point 2.

**Point 4.** Symmetrical, located on the posterior surface of the back 1.5 cun to the side from the posterior midline. The patient lies on the stomach, a pillow is placed under the stomach. The point is massaged simultaneously on both sides.

**Point 5.** Symmetrical, located slightly below point 4, 1.5 cun to the side from the posterior midline at the level of the gap between the spinous processes of the IV and V lumbar vertebrae. Massaged as point 4.

**Point 6.** Asymmetrical, located on the anterior midline...

**Point 7.** Symmetrical, located on the back of the hand... The patient sits.

**Point 8.** Asymmetrical, located on the abdomen, 2 cun below the navel. Massaged as point 7.

**Point 9.** Symmetrical, located on the back of the hand above the upper edge of the wrist by 2 cun. The patient's hand is placed on the table with the palm inward and massaged alternately on the right and left.

**Notes:**

1. Massage of points 2-6, 9 is performed with a soothing method: with light pressure and stroking. Duration of exposure to each point — 3-5 minutes.

2. Massage of points 1, 7, 8 is performed with a toning method. Exposure to point 1 occurs with the use of pressure and vibration stroking. Points 7 and 8 are massaged with the use of a combination of deep pressure and stroking, gradually slowing its tempo.

Massage of the following points is used when allergy is accompanied by swelling (picture 2).

**Point 1.** Symmetrical, located on the back of the hand between the thumb and index fingers. The patient sits, placing the palm down. The point is massaged alternately on the right and left.

**Point 2.** Symmetrical, located on the inner surface of the forearm above the wrist. Massaged as point 1.

**Point 3.** Symmetrical, located on the little finger 2 cun above the nail bed in the direction of the finger. The patient sits, placing the hand on the table. The point is massaged alternately on the right and left.

**Point 4.** Symmetrical, located on the inner surface of the shin above the ankle. The point is massaged simultaneously on both sides.

**Point 5.** Symmetrical, located on the foot in the depression behind the Achilles tendon. The patient sits. The point is massaged simultaneously on both sides.

**Notes:**

1. Massage is performed with a toning method using deep pressure and vibration stroking. Duration of exposure to each point — 0.5-1 min.

2. Massage is performed 1-2 times a day until the swelling disappears.

### Page 4 - Continuation of Acupressure

If allergy is accompanied by itching, then the following group of points is acted upon (picture 3).

**Point 1.** Asymmetrical, located on the spine between the spinous processes of the VII cervical and I thoracic vertebrae. The patient sits, tilting the head forward.

**Point 2.** Asymmetrical, located 6 cun above the anterior hairline. The patient sits, slightly tilting the head forward.

**Point 3.** Symmetrical, located on the outer surface of the thigh above the kneecap. The patient sits. The point is massaged simultaneously on both sides.

**Point 4.** Symmetrical, located on the shin 3 cun above the ankle. Massaged as point 3.

**Point 5.** Asymmetrical, located on the spine between the spinous processes of the VII and VIII thoracic vertebrae. The patient lies on the stomach, a pillow is placed under the stomach.

**Point 6.** Asymmetrical, located on the abdomen 1.5 cun below the navel. The patient lies on the back.

**Point 7.** Symmetrical, located on the inner surface of the shin below the knee. The patient sits, bending the legs. The point is massaged simultaneously on both sides.

**Point 8.** Symmetrical, located on the back of the foot in the middle of the popliteal fossa. The patient sits, extending the leg. The point is massaged simultaneously on both sides.

**Point 9.** Symmetrical, located on the outer side of the hand at the beginning of the crease formed when bending the elbow. The patient sits, placing the hand on the table with the elbow bent. The point is massaged simultaneously on both sides.

**Point 10.** Symmetrical, located on the inner surface of the leg in the area of the popliteal crease. The patient sits, slightly bending the leg. The point is massaged simultaneously on both sides.

**Point 11.** Symmetrical, located on the middle of the lateral surface of the foot on the side of the big toe. The patient sits. The point is massaged simultaneously on both sides.

**Point 12.** Symmetrical, located on the foot in the area of the ankle. The patient sits. The point is massaged simultaneously on both sides.

**Point 13.** Symmetrical, located in the middle of the inner side of the shin. The patient sits. The point is massaged simultaneously on both sides.

**Point 14.** Symmetrical, located 3 mm from the edge of the nail bed of the little toe towards the 4th toe. The patient sits. The point is massaged simultaneously on both sides.

**Point 15.** Symmetrical, located on the shin 5 cun above the ankle on the outer side of the leg. The patient sits, with the outer side of the lower leg resting on the knees. The point is massaged simultaneously on both sides.

**Point 16.** Symmetrical, located on the border of the outer and inner surfaces of the hand at the level of the wrist on the side of the little finger. The patient sits, bending the fingers into a fist. The point is massaged simultaneously on both sides.

**Point 17.** Symmetrical, located on the border of the plantar and dorsal surfaces of the foot at the level of the heel. The patient sits. The point is massaged simultaneously on both sides.

**Notes:**

1. Massage is performed with a toning method using deep pressure and stroking with vibration and rotation. Duration of exposure to each point — 0.5-1 min.

2. Massage of points 10-13 eliminates itching on the inner surfaces of the limbs and the front surface of the trunk.

3. Massage of points 14-17 eliminates itching on the outer surfaces of the limbs and the back surface of the trunk.

Antihistamine preparations by a new generation. Effectivity, appreciation, and base for selecting.

 Ache conditions enduring bad by any of us, allergy rhinitis, dermatitis kinds, tearing and bronchial asthma are small part of these displays, which is dangerous an allergy reaction. Edemas are hard kinds forms of allergy, that is process provoking a most cases with lethal result  and of a not timely first aid added.Now is surgery full introduction, banal use a pill against allergy. And for peoples, active affecting by allergy  always by order keeping antihistamine remedies a close with you, this is hard and not jokes. World medicine  is developing for a human benefit as livers for earth filling, thus and anti allergy pills too entering ,hat affecting in 20 min after using. They are creating for an effectivity help for you as an awesome stat for extreme effect and without side effects .A few of us heard about these remedies, not everybody  a quality understood theirs ,which going buying. And you need to know which effect having an every component containing, and which principle difference having from an own more earlier  predecessors. 

All generations  for antihistamine remedies.

Are all antihistamines having a one effect of principle, as blockading receptors for histamine, and thanks to this a suppression reaction happening for all inflammatory processes. And for an all, every remedy prescribing by your doctor, if not, you  are getting side effects, over dosages .

Antihistamine preparations for a first generation.

 A human long time though about healing remedy ability fighting allergy, thus an assortment for remedies today is a very big, and they are difference by own functional categories , qualities. Dosages, individual remedy containing, force for displaying of side effect , non-comfortable effects, habit in an constant using and a long time using his.

New generation remedies having a following difference characteristic: Effectivity for components are high, improving getting faster, but a prolonging is needing good wishing. That   in 6 hours he is loosing a force and condition is ability faster worsening, after a needing adding next pill using, but a minus here is string sedative effect.

2nd generation. And these are very good legitimate and tests structure, and creating very save for using. And reception theirs today is not popular, but they are not having sedative effect, like  the other . Components not affecting negativity on vital organs  and mental abilities of patient s .

Quantities  for side effects are decreased, but remember, 2 nd generation remedies are avoiding using in cardiovascular diseases, and in heart aches you need to ask or know to which generations they are entering.

For 3 th generation.

 They are very famous on today, same,like  in  2 nd  by components, but more improved formula, as uniques abilities with an absence reaction on the cardiologic functions, where before this effect not received. And effects here on a many times higher, than in last. Are allowing using at work, where needing high attention and focusing, so as remedies not having a visible side effects.

For 4 th generation.

A most tested, modernized and studied categories, effectivity is high, and effecting faster and quality. Temporary period having for a positive effect on the blockage histamine remedies. And not hard affecting for the life activity of organism, and not touching nerve system. An  awesome structure allowing fighting with a string forms of displaying allergy reactions.

 A self prescribe remedy is avoiding, and not matter if he is good too, non control using is avoiding, needing specialist consultation. With allergy,  you know, that these new generation remedies liquidating just new external symptomatic, but a not fighting reason. A better doing all organs' investigation, that  to find a first source for a bad condition. Any pharmaceutic  knowing or therapeutist separating remedies on generations, thus to the use are welcome new preparations with a minimal side effects for you.

And for children's too, new remedies needing prescribing too, just he is adequately rate situation and to advice needing dosage!  

 

Antihistamine preparations by a new generation.

 Allergy reaction displaying in peoples on any age, status, social position, and level for financial position.A not knowing individual between are she is having different handwriting. A  base symptom of allergy on the one irritate  in different peoples is finding not identifiably.

Are a few active forms for allergy reactions displaying :itch /urticaria/, throat ache, discomfort with, sinuses bad feeling in, stuffy nose, heterogeneous rashes on skin. Symptomatic this is bad affecting on organism, lowering immunity and worsening common condition. Allergy principally not displaying on the one place, localization of damaging effect traditionally displaying in a most suddenly places. Sometimes allergy destroying your working plans, trip, life rhythm habit, so as not an always  histamine remedies having in your bag, and theirs effect having a not fast. Against allergy suffering lots of us, atopic dermatitis affecting children's, and a special attack having on spring, when around is all blooming, smelling. Pollen of herbs opening is affecting on your life, as destroying her, and against hard symptoms noting saving, just eight selected remedies.

Self allergy is not having, and having affecting on other life organs, and patients often allergy affecting, having risk a bronchial asthma, thus you must regularity investigating organism, excepting possibles for developing pathologic changes, and remedies using here needing with doctor consulting.

 Principles  of effect are anti histamine remedies.

Allergy is displaying of immune system sensitivity to protein-antigen, in a contact with allergen is activating forcers of immune system, by speed of effect, all allergens are separating on two kinds:

Fat type of effecting. His   symptomatic are displaying on a first 24 hours, minimal threshold of reaction displaying are a few sec. Acute process displaying, active substances free  from tissues, a one from these is histamine, thanks to him, displaying inflammatory process, which reflecting on skin or mucus membranes, with not stopping itching, tearing, strong cough, or stuffy nose. Saving happening after anti histamine taking.

Slow type of effecting.  A first symptoms displaying are 4 days, answer immunity forming a few days, thus inflammatory process activating a longer time. Responsible for organism reaction and answer of immunity is histamine, for a start inflammatory process are needing histamine connecting with receptors of cells structure. Antihistamine containing having a place for histamine receptors, hope blocking developing process for inflammatory. Entering in the blood, antihistamine remedy an awesome working with an own function, but his fastening  effect having of a level manufacturing a remedy. Interval of time, through a which happening blocking of irritate , having a importance temporary scatter . But,  result is one" condition of patient improving, allergy displays calming of  stopping displaying.  

Peony.

 In the roots of pink peony having micro-elements , tannins, sugars  ,alkaloids, starch, glycoside salicin , essential oil. Spirit tincture.

1/4 glass of root  chop, add glass of spirit, infuse 4 weeks, use for two months for 3 times/day on 30 drops in allergy.

Powder for a cure allergy vasomotor rhinitis.

A peel of tuber root chop, use powderb3 times/day on 1 tbl.sp. for a week. And by experience an effect from a cure begun on the second cure date. A stuffy nose stopped.

A poison herb, check dosages, avoiding in pregnancy.

Primula.

Against allergy.

1 tbl.sp. of fl. adding in boiled water, infuse in thermos for 20 min, filter, and infuse for half hours. Use on half glass for 3 times/day.

 Bath with primula.

Dried mass grind, use 300 gr of powder and add 2 l. of boiled water, infuse in closed dish at room for 45 min, filter through  two gauze layers, press through gauze,add in water for bath and mix.

Warm  water take in , from 15 to 25 min, on 15 a full cure course are 10–12  baths on enough, in a day taking, alternating with an other anti allergy baths. And  they are good anti allergy effects having, anti-inflammatory , improving activity for endocrine glands and good for blood creation.

 A strong infusion on an  empty stomach taking causing nausea, in atonic   bowel, with hard stools avoiding using primula for the long time.

 Mint piperine.

Against allergy.

2 gr of leafs mint, 5 gr of fl. viburnum, 8 gr of roots licorice naked, 3 gr of root inula helenium, 2 gr of leafs sage, 5 gr of fresh herb horse tail field. 1 tea.sp. of mixture add in 1 glass of the hot water, infuse 6 hours in thermos.Use 1 tea.sp. till 1/2 glass for 6 times/day before a meal.

Mint tincture in allergy dermatosis.

 As on 1 to 5 tincture cooking, 20 gr of dried herb,add 100 ml. of 75 perc. of spirit or vodka, infuse 2 weeks in dark place, use on 10-15 drops for 3-4 times/day.

A mint avoiding giving for babies till 3 y, old , lowering vessel tome, thus not use in widening veins, she is relaxing herb, not after driving for car, avoiding using her a much, and in hypotonia, and lowering potency.

Acorus calamus.

In nettle rash, allergy.

Roots of acorus powder add in honey, one to 1, use 6 gr of remedy for night.

 Avoiding high acidity for gall bladders, and entering in mixtures with herbs are suppressing high secretion of salted acid.

Valeriana.

Against allergy.

1 tbl.sp. of valeriana roots, 2 tbl.sp. of anise root, 2 tbl.sp. of leonurus lobed, 4 tbl.sp. of oregano herb. 2 tbl.sp. of hypericum perforatum, 2 tbl.sp.narrow-leafst willow herb , 2 tbl.sp. of sewing flax seeds, 3 tbl.sp. of coltsfoot leaf.

5 tbl.sp. of mixture add in thermos, add  1 l. of the hot water, infuse 6 hours in a cure for allergy reactions,Drink for 5 methods in 20 min after meal.

 A long using Valerian  causing worry ness, gastric disorders, hard stool, headaches, in chronic enterocolitis causing acuting for disease.

 Field scabius.

A tea for allergy.

4 tea.sp. of herb in 400 ml. of the hot water, use 1/2 glass for 4 times/day.

1 flower for children, or three for adults chop, add 1 glass of the hot water, infuse.

Use on 1/4 glass for 4 times/day.

 Infusion in allergy dermatitis.

2 tbl.sp. of herb add in 0.5 l. of the hot water, infuse for 1 hour   ,filter. Use 1/2glass for 4 times/day, and use externally.

In a different dermatitis style causing acuting, and feared patients stopped used herb, and here use patience, and keep cure.

Red clover.

Against allergy. 1 tbl.sp. of chopped  mass add in glass of the hot water, infuse for 1 hour, filter, use 1/2 glass for 3 times/day before meal.

Inflorescences 20 of clover cook 15 min in 250 ml. of water, infuse 30 min, filter. Use   on 50 ml. for 4 times/day. Or in 1.5 hour after meal, 0.75 glass for 3 times/day.

Avoiding clover using in pregnancy, and  breastfeeding.

Calendula officinalis.

In allergy on the pollen.

10 gr of fl. add in 0.5 glass of the hot water, infuse 2 hours, use 1 tbl.sp. for 3 times/day.

 10 gr of fl. add in 200 ml. of the hot water, cook ten min, use 1 tbl.sp. for 2-4 times/day.

 Rare she is cures  allergy, in high sensitive avoiding calendula using.

Inula helenium.

Bath  with infusion of inula helenium in allergy dermatosis.

300 gr of root add in a basin of water, boil, like compote, infuse for 4 hours, a cook bath ,that a full entering in water, add infusion.

Against allergy.

1 tea.sp of roots add in 1 glass of the hot water, infuse 3 hours in thermos, use before 20 min to the meal on 1/3 glass.

Relieving skin itch in urticaria.

A cook decoction of roots as of 1 to ten, boil for en min, use 1 tbl.sp. for 3 times/day.

Avoiding in kidneys diseases, pregnancy, in hard cardiovascular diseases also.

 Filipendula ulmaria.

1 tbl.sp. of mass add in 500 ml. of the hot water, infuse 10-15 min, use one tbl.sp. for 3 times/day.

 And on begin allergy displaying are decreasing and in a few months of cure  are stopping a full.

 Avoiding in hard constipations, chronic, astringent effect having,  and he is having anticoagulation effect as containing salicylates, thus bleeding affecting on in a bad blood coagulation peoples and thrombocitopenia . 

Lowering pressure as in hypotonia care using or use in adding leuzea, golden root.

 Burdock big.

1 tbl.sp. of root add in 200 ml. of the hot water, use warm on half glass for 3 times/day in eczema .

In eczema .

10 gre of roots big add ten gr of dandelion roots. 20 gr of mixture  add in 200 mm of the hot water, infuse ten min, filter . Use 1/2 glass for 4 times/day.

Ointment of burdock roots for allergy dermatosis.

 75 gr of   fresh chopped root, infuse for day in warm place in 250 ml. of sunflower oil, better is almond. After cook on 15 min on weak fire, filter. 

Bath of roots.

Dried roots chop add cold water as 50 to 100, boil half hours, filter. Water bath in bath fill in with infusion, use for night in eczema ,lichen, skin pus damage, alopecia , course are 12–14  baths.

Avoiding burdock using in pregnancy!  

Dandelion.

Useful parts.

Roots are having rubber, bitterrness, polysacharid inulin, fat oil, sterols , raisins, organic acids, tannins, and protein substances, mucus.

In leafs are choline, carotenoids, vitamin B2,C, PP, iron, asparagine, phosphorus, calcium.

 A juice of dandelion in allergies.

On the blooming time a dandelion take leafs of herb, wash from mud, dry, to mince meat, wrap in two layers of gauze, press juice, and dilute juice in water as one to one, lead till boiling .

Use 3 tbl.sp. for 2 times/day before meal.

 Infusion of dandelion in allergy on the meal s products.

 Tea.sp. 1 of chopped roots dandelion, add in 1 glass of hot water, keep ten min on weak fire, cool, filter. Use on 1/3 glass for 3 times/day before meal.Roots you can grind till a powder and cook,like coffee.

Avoiding dandelion in acute conditions with blockage of gall ducts, care for in high acidity as ulcer disease, gastritis, in over dosage causes vomiting, sickness.

 

Alternative remedies against allergy.

 Yarrow is allergy  cures.

Hello.Am an  allergist with a big experience, am having an allergy on the pollen  and dust of herbs, every spring eye  are red, tearing and sneezing. And am looking very pale with red eyes. Though about a covering my face full. Used all traditional and not traditional methods, without results.Am endured 4 years, that remedy found against allergy acuting it is dried yarrow herb. You can prepare her from fields , or buy in pharmacy.

2 tea.sp. of herb yarrow add in hot water in 400 gr of cup, in ten min filter, use on 1/3 glass, like tea for three times/day.

 If am feeling, that  allergy is increasing am  using for night are two portions. On the morning disease not attacks me. One day am used infusion for two months   on an every 4 hours, and avoiding a nighttime. Will be a happy if  will help for you.

Our expert: Yarrow simple having azulene   substance, which having anti allergy effect, azulene  having in chamomile field, herb of hypericum perf, inula helenium, nettle diclinous.

 And in skin itching, apply lotions with infusion of simple yarrow, and in neurodermitis are helping baths with yarrow infusion and sage. They are relieving condition, softening crusts as in scratches  having. Skin on the under knee and elbow bends will be a soft, and  vitality. Yarrow fighting inflammatory process, itch is stopping.For a visible effect baths with yarrows using a regularity.

Against nettle rash steam with a broom.

My friend  is suffering from urticaria , as 20 years lived with it. Injections, pills are not helped.And  often used sun baths, though its helps, also not helped. Half of this date used dimedrol on an everyday, but she often slept, but a true cure of nettle is simple, that one woman shared in a train, where they are both met. At sauna steam with broom of nettle, but on winter, she is not had nettle broom, she had a birch. She is  used 3 seances and nettle rash is removed. And 20 years she is not ability cured, but recipe is simple. And within many years later, she is not returning to her, but for preventing she is still visiting sauna.

A nettle against urticaria.

Am sicked on winter from nettle rash, but where to take fresh nettle on winter?Am visited doctor. A remedy she prescribed, but without results. And skin itch stayed stronger. Am remembered, that  since summer am prepared dried nettle. Am,as on summer swam  in nettle bath, when my grandma advised , am healthy now.  And use nettle, cooking in a big basin, and after this infusion add in bath, and swim. And in 3 days such cure ,she will leave  you. Also,  you can use a dried nettle.

 Kalanchoe.

 A having herb are 200 kinds.

Fresh leafs or juice of herbs using , and cutting leaf before using.

Juice of leafs and stems having organic acids, as apple, sorrel, lemon, vinegar, tannin substances, vitamin C, micro-elements and polysaccharides.

 And juice quantity getting, use juicy leafs, meaty. Juice  is containing from 2/3 herb structure .A  process for juice preparing is simple, leafs needing will be fresh, juicy. And on the preparing times, cooking a stuff in cool, and dark place to keep.

A fresh juicy, meaty leafs add in press and for week put in cool place. After  grind in not metallic dish, close and put again in cool place for 48 hours. After filter juice. Add spirit , against his souring , as 10 ml. on 1 glass of juice. And for 18 months for you can use this remedy.

In allergy dermatitis. 1 tbl.sp. of fresh juice dilute in cooled boiled water as one to 4, doing lotions on skin red and itch.

For lotions.

1 tbl.sp. of chopped leafs add in 100 ml. of 40 perc. Spirit   and infuse in warm place for ten days.

 After filtering a tincture use for lotions in allergy dermatosis, eczema.

A kalanchoe ointment.

15 ml. of juice add in 25 gr of lanolin, add 25 gr of  Vaseline , mix till a same mass. Use in allergy dermatosis.

And avoiding kalanchoe using in pregnancy, allergy on the herb, liver diseases as cirrhosis, hepatitis, joints diseases, low pressure, tumors.

 

Which dyes are causing allergy?

 A paid attention on these notes and additives!

 E100, E101, E102,E104, E107, E110, E120, E122,E123, E124, E127, E128, E129, E131,E132,E133, E140, E141.

Try to do not buy gene-modificated products.

These are 120 kinds of products having are soy, corn,rice, cotton, pumpkin, cucumber, pepper, potato, and scientists not hide and warning you about an allergy these products. And trans gene - proteins using in baby s meal, in milk mixtures, sausages, confectioneries, drinks .

Within 5 years are allergic children is increasing, and not sharing about an negative results for health will be.

A try not drink alcohol .

Alcohol  increasing blood flow, and accelerating meal absorption  components  by stomach membrane and bowel, and also alcohol  accelerating effect of meal s allergens .A reason for bad enduring a wine is sulphur, mold, histamine,white egg.Reasons for bad enduring a beer are humulus, malt, yeasts.A most peoples are good enduring alcohol , as vodka, fruit wines, but remember in vodka and liquors  often adding exstracts and aromatic substances with a spicy tastes, nuts or fruits. 

An old remedies against nettle rash.

Every of fifth from us a one time in a life had  itched diseases is urticaria, angioedema, edema Quincke , and they are attacking you as separately, or together on a half cases. An sometimes a not easy defining reason for displaying on the body a rash and bladders, and a most often causing by allergens.

Symptoms of urticaria. And symptoms ,like by nettle burns, pink, in pressing are place bladders on 1 mm till a few cm ,till a strong itching , and get a call of this too. Rising temperature, weakness, headaches, and urticaria damages in predisposition  to her are patients for skin parts or all body.

And peoples  ,who affecting these itched disease, are needing using these simple rules:

Wash, swim hands in warm water , avoiding hot sauna, bath, ice , contact with ice water, not take in hands cube ices.Avoid hard sorts of soap.

After swimming apply on skin moisturising  remedies, rub a soft towel.

Wear free cotton clothes.

Avoid staying in hot places.

A not use aspirin, if disease attack calmed.

Avoid stress, use calming remedies.

And preventing urticaria and of edema Quince and angioedema are herbalists advising from a time to time eating vegetable meal, avoiding fat meat, pork, bird, spicy snacks, wine. And effectivity are herbs too.

 Burn woods, ash clean add in water, boil, infuse, filter, and this infusion a washing.

 50 gr of roots raspberry boil on weak fire for 20 min, infuse for 1 hour, filter, use 1/2 glass for 5 times/day.

 Shred celery root or to mince meat, squeeze, us 2 tea.sp. for 3 times/day before meal. or 2 tbl.sp. fresh roots chopped infuse 2 hours in glass of cold water, filter, use 1/3 glass for 3 times/day before meal.

1 tb.sp. of herb yarrow add in 1 glass of hot water, daily dose, infuse 45 min, use 1/3 glass for 3 times/day before meal.

1 tbl.sp. herb add in 1 glass of the hot waster, boil ten min, use 1/3 glass for 2 times/dsay before meal. Or dried herb add in 70 perc. of spirit, as one to ten, infuse 7 days, use on 40–50 drops for 3 times/day.

 And yarrow herb infusions are very high anti allergy effects having, blood cleaning, normalizing metabolism.

Dried duckweed use as powder 1 tbl.sp. for 4 times/day before meal, with jam or honey as daily dose on 16 gr, as fresh kind eat as salad, slightly  salting and adding vegetable oil, daily norm is 30 gr.or 1 tbl.sp. chopped herb add in 100 ml. of the hot water, infuse 10 min, drink right away, use for 4 times/day.

 30 gr of leafs nettle deaf as lamium album in 0.5 l. of water add, boil leading to, cook on weak fire 2-3 min, infuse for 1 hour, filter, use for lotions.

10 gr of infloresc. calenidaula officinalis in 1/2 glass of hot water, steam for 1-2 hours, use 1 tbl.sp. for 3 times/day.

 ACrataegus drops and valeriana to mix, use 30 drops before sleep with water.

And for a full recovering changing caffeine and tea on fresh bidens tripartite infusion, cook his, like  tea, use in 20 min without limiting, golden infusion is must to be, if green, murky  ,thus she lost an healing effects.