Which role plays fat and leptin in insulin resistance?

 Gain for lipogenesis de novo/forming fat and weak lipolysis as splitting and decreasing fatty mass in fatty tissue are depending from glucose level in blood, and quantity of insulin, secreting by pancreas gland. Lipogenesis gain in a high level of glucose in blood, and lipolysis in low. A many quantities of insulin stimulates lipogenesis ,and small quantity of insulin inhibits /depresses/ a lipogenesis. Thus, abundant  of glucose in blood and high level of insulin stimulates forming and depositing fat in insulin resistance peoples. Remember it! Thus,   a one from base methods   ,which helps keeps a normal weight and avoiding  rising level of glucose and insulin.

Fatty tissue secrets a whole rows of biologically active mediators, calling adipokinesis /adiponectin, leptin , hemerin, resistin, visfatin, and  vaspin/. in additional to cytokines and chemokines  /factor necrosis of tumor -alpha  -a, interleukin  -a 6/IL-6, IL1b, and  monocitary  chemoattractate protein-1. Destroying and manufacturing these  adipokines, ties with increasing of size a fatty tissue n obesity and decreasing her split, associating  with obesity insulin resistance , diabetes 2 nd  type, cardiovascular diseases, hypertension, and different metabolic destroys. Thus, a this  fat, which having  in your bad is hormonal active organ, which a self to cause a disease , if he is abundant and deposited in wrong place, where is not must to be, and if he is not much. Thus,  a fat is a neutral  fat.

A let s detailed check are two importance adipokine  a hormonal same substance adiponectin and leptin. 

Adiponectin is a most secreting  protein of fatty tissue , as with a power anti-inflammatory   effects , and in compare from other adipocines, in obesity  and insulin resistance a level for adiponectin  is lowering under affecting of ant inflamed agents/TNF-a, IL-6, ROS, that allowing predisposing  ,that  chronic inflammation tie with insulin resistance and contrary.

Leptin. Also,  hormone saturation, is cytokine ,which manufacturing by fatty cells.As in norm he is affecting on weight lowering, manufacturing glucose level lowering in liver, normalizing level of glucose in blood and rising sensitiveness of cells to insulin,that is useful and importance!Leptin depressing manufacturing insulin in beta-cells of pancreas gland,that helping to prevent insulin resistance of tissues. Insulin here stimulates secreting leptin from fatty tissue, creating a loop of back connect with hormonal regulation.

  And am sharing detailed this. Stomach hormone is ghrelin   is starving hormone rises appetite and eating meal, and leptin is saturation hormone, manufacturing by fatty cells, lowering appetite and meat eating. When you are eating, organism manufacturing leptin, level of which slowly rising, and saturation feeling ,when leptin level lead a limit, signing for brain ,that you are saturated, your stomach is full. Insulin, level of which also rising and on the time , lowering feeling starving in healthy peoples  and stimulates secreting leptin, but leptin beginning depressing manufacturing insulin, so as a slowly rising till a high levels and on the meal time.

And these substances are affecting on inflammation development, secreting by abundant peritoneum fat, liver, and immune cells of blood. Adinopectin also manufacturing by fat, as more  in organism quantities of bad food,thus a more  manufacturing these inflammation substances, which depressing a positives anti  inflamed effect of adinopectin , causing an inflammation.

 An importance!If you are over eating and having obesity, or in your ration are much carbohydrates , your organism can be manufacturing much leptin, than usual , that lead to the calling leptin resistance  is lowering of cells sensitiveness to leptin , analogically  in insulin resistance. And this low control over hungry feeling and rising development for insulin resistance. And contrary,  a chronic raised level of insulin in blood and insulin resistance  also rising level fo leptin in blood and affecting for development leptin resistance. A high level of leptin in blood with obesity  and insulin resistance affecting on removing anti-inflammatory /affecting  for inflammation such connects as IL6, TNF-a, IL-12  , SO ARE ALL CLOSED TIED!

Other extreme is leptin deficit , as meeting rare. Deficit such lead to insulin resistance , which will stay a reason for hard and hard curing forms of diabetes, and triglyceridemias rising triglycerides in blood, which lead to pancreatitis, such patients an still not saw.

 Ideal test on leptin resistance is not having , and most spreading  is a calculated for index free  leptin, which doing at hospitals, as specializing on metabolic destroys, but in Estonia , non hospitals is not defining index for free leptin.  And defining simple leptin in blood on an empty stomach is having small diagnostic value-his for example is ability to check with insulin on an empty stomach, but am this test using rare.In women's leptin level is not must to rise on 7-10, in males are 4 units on a morning emptiness.

Losing weight is affecting an importance on insulin effect,and lowering weight on 5 perc. Improving sensitiveness of many organs/fatty tissue, liver, and skeleton muscles /to insulin.