Obesity is not surrending for curing.

 Prader  -Willi  syndrome/PWS/ IS example for not curing diseases by genetically conditioned and displaying with hard destroys of feeding and metabolism.

And base symptoms  are here hard hyperphagia is insatiable appetite, leading to obesity, delay growth, characterizing  physically peculiarities, hard in learning, behaviour and psychical problems course of  disease variating from a case to case and from light to hard and progressing within all life.A reason for PWS is absence or failure functioning certain genes or genes parts on 15 father s chromosome .PWS is inborn genetical anomaly,  thus her is not possible to cure . But if disease found on an early stage and cure begun /as with hormones to grow and other preparations /, prognosis staying more optimistic. And still one form for hard obesity kind, which differencing from other obesity types is monogenic obesity, causing mutation in a one from key genes, answering for weight lowering. And just meeting in 5 per. of peoples with a hard obesity forms and display on the childhood. An EXAMPLE IS serves inborn deficit of leptin ,which lead to non-controlling appetite rising.

  https://www.youtube.com/watch?v=sKEFcM1QUVs&pp=ygUSdGxjIGxlcHRpbiBob3Jtb25l