Mediators and receptors.

Within 30 years researchers of migraine are studied a base substance of cerebral brain is serotonin, as he is narrows are big blood vessels and vasodilate are more small, and showing an importance information substance in brain is mediator. As switching schemes with serotonin as information substance are taking part in regulation for sleep, mood , and ache absorbing.And on these schemes affecting are female sex hormones are estrogen, which a quantity theirs changing is on the menses cycle.As serotonin filling in body, as in blood s plasts are thrombocytes and refree to the begin of migraine attack. Red wine also lead to the high refree of serotonin from thrombocytes,which in migraine patients are not stable,than in healthy persons. Manufactured a remedy against migraine as zumatriptan is evidenced for the central role of serotonin in the migraine attack time.

As zumatriptan,like by a chemo structure is serotonin, and affecting against migraine headache and attendance diseases in the especial places for connects are receptors for serotonin with a vessels of cerebral brain.Triptan and ergotamin are antagonists for serotonin, or an other words are substances these stimulating receptors for serotonin. Agonists for serotonin as narrow vessels and not affecting on the migraine aura.
And vessels,as theirs walls endothelias manufacturing substances,which are having a meaning for migraine.As this is Oxygen  nitrogen NO and needing for the getting NO in the vessel of vessel synthesis of oxygen nitrogen NOS are played role for sensibilization of trigeminovascular system and ache vasodilating and penetrating of vessels a cerebral brain.