Why a role of liver is importance in insulin resistance?

 Am explained , insulin resistance is development in muscle tissue , and that lead to increasing delivery of glucose in liver. That is lead to increasing fat manufacturing where is not must be .And,  after this is goes insulin resistance development in fatty tissue, leading to paradoxical high splitting fat in fatty cells ,that increasing quantity of  free fatty acids in blood current and more aggravating muscle and visceral fatty acid and insulin resistance for muscle tissue.

In absence of  insulin resistance as in metabolic health condition is insulin , secreting in meal eating, lowering manufacturing glucose in liver , suppressing glycogenolysis is process, in a course of which organism over digesting are stocks  for glycogen, having in liver. Pay attention ,its   a not a same, that glycogenesis,when,   instead glycogen  a glucose manufacturing from an  other predecessors,as lactate, amino acids   etc. And in peoples with insulin resistance a high insulin level stimulating glycogenesis  , or splitting glycogen, in liver through different mechanisms , and in healthy peoples an  insulin lows glycogenesis .And,  in peoples with insulin resistance liver a staying constant source for additional manufacturing glucose in blood, that lead to constant a rising level of glucose in blood.

Thus,  in insulin resistance a liver keeping splitting glycogen ,but in norm  this is not must to happen. Manufacturing by liver a glucose keeping always, even when glucose level  after eating a meal is not high. After every meal time a level of glucose in blood  rising is higher  , thus organism not ability assimilates her  and to spread n cells and abundant glucose in blood   will affect as toxic on different cells  , that aggravating insulin resistance and inflammation.

 And you can to see  a cascade of processes  which precedes ,accompanies and follow  to  development of insulin resistance is very hard. But,   a most importance for you, that we are to influence   on this cascade ,thus for this and dedicated   a most part from book.