Why in one peoples development metabolic destroys and insulin resistance, and in other is not?

 Insulin resistance appearances    in human tied as with inborn within all life reasons , and with genetic factors certain.  As am shared before about a different genetic profiles  as hunter-gather, farmers, mixed profile .And,  a last  genetical and biochemical researches are allowing  to predisposition, that substances , secreting by abundant fatty acids  in body affecting on development insulin resistance in other tissues, besides an own fatty tissue. Different researches are shown , that in women on pre menopause are less metabolic destroys, than in males, including and insulin resistance. Against insulin resistance are protecting female hormones as estradiol, and differences in energy costs on a calm condition, fatty metabolism and predisposition  to  fatty disease of liver and visceral obesity /condition in which a fat depositing between inside organs of peritoneum cavity/also affecting on a low risk for development insulin resistance in women.But,  its difference is decreasing as when women entering in post menopause, when estrogens quantities is lowering and dominating testosterones displaying as affecting on depositing fat in belly. As ageing, fatty women's and males looking are same. A few genetical researchers are shown  ,that different parts of genes tied with insulin level on an empty stomach, rising levels for triglycerides and lowering a level for a good cholesterol /HDL/, THAT IS DIFFERENT SIGNS FOR INSULIN RESISTANCE.

  Despite on potential genetical factors , on the share such variants are falls just on 25-44 perc.  of cases,  a genetical insulin resistance . That  means, as a development or absence of  insulin resistance,  are on the 50 perc.  more is depending on from life mode , but not from a genetical predisposition  .And,  assumption not meaning, that in you will be development  insulin resistance, as all depending on from your life mode, and it's  a time to think about it!

And not to think , that insulin resistance  having as itself its false, she entered in all  processes in organism. And, a work all systems  of our body is hard, that a most  happening process we are just opening!

And,  let s to add example.

If we are :

1. A not enough and not quality to sleep, that lead to melatonin deficit, stress, and to dysfunction for thyroid glands.

2.We are not getting enough  quantities for useful and right microelements in ration.

3. And not attention  on  hide sugars, trans  fats, canned food in fast food.

4. Not enough using sport.

5. Long time using computer, gadgets, phones as in artificial light, as poor time using natural light  as a sun.

All these are leading to are many chemical reactions in organism are not ending.

 And so not ending ,so as organism planned them ending.

 So as if your organism counting ,that your sleep are 8 hours, as he will over build all inside processes. But,  if you are sleeps just 6 hours or not sleep, as using night work, clubs, thus in 6 hours a few molecular and physiologic processes, which are need stopping just in 8 hours ,faster stopping.

As think about, you are cooking soup, and cooking time is 1 hour, but on 40 min for you are called and asked  work, and soup kept not cooked, so,  as on a table keeping potato peels and meat pieces,which are in a few will spoil. Half cooked soup as in an oven kept, is having a place for other dish, which you are want to cook a next. Organism too planned to do still is  on an end this   process concrete is over build into cell trash, grow new healthy cells, manufacturing hormones and etc, but not ability done it, that you are gone in bed on one hour a.m , not on 21.30 pm, or woke up on 3.am of an early change, that you must to be at work on 4.30 am.So,  a same happening and with night changes, when circal cycle regularity destroying -organism is every time has on an every time to begin own processes  again.

 This is metaphor ,that happens, when all goes  not by optimal way, manufactured by organism , as dictated for him by us  as by modern peoples ,which are not care about real needing of our body.

But return to organism , when these are stopped cycles repeating, in cells are beginning accumulating intermediate products for metabolism, which are over manufacturing or splitting. Toxins and fragments of not over manufactured structure elements also keeping in cells. These molecules are not having systems for self-destroy and not damaging cells. Organism beginning searching methods for using  and utilization these substances, that needing additional energy and accelerating processes for over manufacturing and removing. A needing in additional energy for supporting a clean of inside environment of organism  is ability to stimulate raised appetite to sweet and fat meal,and to activate forming fatty  deposits.

 That means, your life method is affects  on this, would    accumulate your organism a fat   or stocks  and expenses finding in balance.