Reasons for insulin resistance,

 These are genetical, mixed, and acquired.

 In a most of the peoples with insulin resistance reasons are having acquired.

Base reasons for acquired insulin resistance are:

Abundant for sicked or dysfunctional fat, ageing, failure for physical activity, meal s disbalance, a few remedies for curing rheumatoid arthritis, tumors, schizophrenia and diabetes first type, diet with a high containing natrium, glucose toxicity and high carbohydrate products, lipotoxic   of abundant circulating free fatty acids.

To genetical conditioned reasons for insulin resistance are referring:

Myotonic dystrophy, ataxia-teleangiectasis , Alstoma syndrome, Syndrome Rabson -Mendenholla, Syndrome Werner, lipodistrophy, certain types for syndrome ovaries polycyst /PCOS, insulin resistance type A, characterizing a hard insulin resistance as destroying metabolism of glucose, virilization ovaries and black acanthosis, absence for insulin receptors, usually displaying till middle life, insulin resistance type B, characterizing for development anti insulin antibodies as on middle age, with destroying metabolism of glucose, ovaries, hyperandrogenismus and black acanhtosis.

Am adding,that alternative classification for insulin resistance including a type of place dysfunction of an own insulin receptor , its classification includes just are three kinds of insulin resistance:

1. Insulin resistance as tied in destroying of pre receptors function.

2. Insulin resistance, tied with dysfunction receptors.

3. Insulin resistance ,ties with dysfunction post receptors.

 Attention add, that  SPO, HERE  is genetical predisposition, which rare meeting,than an absent for genetical predisposition, as not an all cases referred for SPO Genetically. And if genetical disease SPO self causing insulin resistance, but not from a reason.

Virilization or maculinization , in women's having of abundant manufacturing female sex hormones androgens /hyperandrogenism/ of adrenals, or ovaries , and destroying metabolism of steroid hormones.

Black acanthosis /acanthosis  nigricans/ is hyperpigmentation  of skin in neck region, groin, armpits, and in other places. And  skin colour in these regions staying darker.

 A constant  raises level of glucose in blood, causing of eating meal with a high contained sugar, causing irreversible damaging a pancreas gland and other organs-calling glucose toxicity.