All ,what is this book shares, creating to insulin resistance as her reason, developent , and preventing.

 A condition of   insulin resistance hinders for splitting of fatty tissue, and interferes for glucose absorption for muscles and destroys process of glycogenesis in liver. And let s remember ,what is glycogenesis:its synthesis of glucose from non glucose precursors  in organism. A such precursors are different molecules,as lactate, is product of anaerobe metabolism of glucose in muscles, glycerine is a product of  splitting triglycerides in fatty tissue and a few amino acids in proteins splitting. After different chemical reactions, these precursors transforming in glucose .Glycogenesis is an importance mechanism for supporting stable level of glucose in blood, as on starving time or failure of carbohydrates  in ration. As allowing for organism keeping getting energy from glucose .and when you are not eats.

A few researches are thinking ,that insulin resistance causing by inflammatory changes in muscle tissue and raised  concentration of free fatty acids, that leading to fat accumulation in places , where his is not must  be. In certain conditions, muscles are ability using till 70 perc.  of consumed glucoses. When an absorbing glucose by muscles are destroying, an abundant glucose returning in liver, increasing manufacturing fat de novo as on Latin means as again, from zero  ,  and quantities for free circulating free acids, that affecting of aggravation insulin resistance and ectopic/as where his is not must   to  be a fat depositing  .Initially , syndrome for insulin resistance incudes are following components:

Insulin-stimulated resistance of absorbing glucose.

Destroying tolerance to glucose.

Hyperinsulinemia or raised insulin level in blood.

High blood pressure.

 Dislipidemia/as destroying cholesterol metabolism, characterizing with raised concentration of triglycerides and low concentration for  a good cholesterol HDL.

Tolerance to glucose is a fast ability fighting from a raised  level of glucose in blood. More raised  tolerance to glucose  ,thus more healthy person in metabolic plan.If tolerance to glucose lowered or worsened, thus, its  a sign  for pre-diabetes or diabetes.

On a last time to this list added central obesity, increasing numbers of small parts cholesterol LDL , rising concentration of urea acid, increased concentration of inhibitor activator plasminogen   1 ,   and lowering concentration of adiponectin.